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CA6 - carbonic anhydrase 6 Gene

Also Known as CA-VI; GUSTIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 765

About CA6

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:8,945,868-8,975,092 (from NCBI)

This gene has 6 transcripts (splice variants), 228 orthologues and 14 paralogues. Restricted expression toward salivary gland (RPKM 1381.7).

Summary

The protein encoded by this gene is one of several isozymes of Carbonic Anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]

CA6 Products (4)

mRNA	Protein	Name
NM_001215.4	NP_001206.2	carbonic anhydrase 6 isoform 1 precursor
NM_001270500.2	NP_001257429.1	carbonic anhydrase 6 isoform 2 precursor
NM_001270501.2	NP_001257430.1	carbonic anhydrase 6 isoform 3 precursor
NM_001270502.2	NP_001257431.1	carbonic anhydrase 6 isoform 4

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Verweise	Source
involved in detection of chemical stimulus involved in sensory perception of bitter taste	IDA IDA: Inferred from direct assay	24248522	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular space	IDA IDA: Inferred from direct assay	24248522	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CA6 Protein Structure

Carb_anhydrase

0
100
200
308 a.a.

Protein Preferred Names	Protein Names
carbonic anhydrase 6	carbonate dehydratase VI

CA6 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P810853	CA VI Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mammary Analogue Secretory Carcinoma
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Enamel Erosion
Tooth Erosion	Generalized Erosion Localized Erosion Generalized Erosions Erosion, Localized
Multilocular Clear Cell Renal Cell Carcinoma	Cystadenocarcinoma Of Kidney Renal Cystadenocarcinoma
Aseptic Meningitis	Acute Aseptic Meningitis Meningitis Aseptic Meningitis, Aseptic
Parotid Disease	Parotid Diseases
Xerophthalmia	Conjunctival Xerosis
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01773	CA6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P991649	Anti-CA6 Antibody (huDS6)		98.03%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CA6	VGNC	VGNC:26656
Mus musculus	CA6	MGD	MGI:1333786
Macaca mulatta	CA6	VGNC	VGNC:70493
Felis catus	CA6	VGNC	VGNC:60277
Canis familiaris	CA6	VGNC	VGNC:38614
Rattus norvegicus	CA6	RGD	RGD:70516
Others	CA6	NCBI