CST7 - cystatin F Gene

Also Known as CMAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8530

About CST7

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:24,949,269-24,959,928 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues and 11 paralogues. Biased expression in bone marrow (RPKM 321.5), spleen (RPKM 27.1) and 1 other tissue.

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human Cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008]

CST7 Products (1)

mRNA Protein Name
NM_003650.4 NP_003641.3 cystatin-F precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables peptidase inhibitor activity IDA
IDA: Inferred from direct assay
15752368 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18256700 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
15212960 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of peptidase activity IDA
IDA: Inferred from direct assay
15752368 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
18256700 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12423348 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15212960 GOA
located in endosome IDA
IDA: Inferred from direct assay
15752368 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
12423348 GOA
located in lysosome IDA
IDA: Inferred from direct assay
15752368 GOA
located in multivesicular body IDA
IDA: Inferred from direct assay
22365146 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CST7 Protein Structure

Cystatin

Cystatin: Cystatin domain (37 - 133)

  • 0
  • 100
  • 145 a.a.
Protein Preferred Names Protein Names

cystatin-F

  • cystatin-7

CST7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CST7 O76096 CTSC Homo sapiens P53634
Anti Tag CoIP
18256700
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CST7 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7851 Cystatin F/CST7 Protein, Human (HEK293, His) O76096 (G20-H145) ≥ 95%, as determined by reducing SDS-PAGE.

CST7 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P86843 Cystatin F Antibody (YA6536) WB, IHC-F Human, Mouse

Related Diseases

Diseases Alias
Cerebral Amyloid Angiopathy, Cst3-Related

  • Cerebral Amyloid Angiopathy

  • Hereditary Cerebral Hemorrhage With Amyloidosis

  • Hchwa

  • Hereditary Cystatin C Amyloid Angiopathy

  • Cerebral Amyloid Angiopathy, Familial

  • Amyloidosis, Cerebroarterial, Icelandic Type

  • Amyloidosis Vi

  • Cerebral Hemorrhage, Hereditary, With Amyloidosis

  • Cst3-Related Cerebral Amyloid Angiopathy

  • Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

  • Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

  • Caa, Familial

  • Cerebral Amyloid Angiopathy, Genetic

  • Acys Amyloidosis

  • Cst3-Related Amyloidosis

  • Cystatin Amyloidosis

  • Hchwa, Icelandic Type

  • Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

  • Amyloidosis 6

  • AMYL6

  • Acys

  • Caa

  • Cerebral Amyloid Angiopathy Cst3-Related

  • Cerebroarterial Amyloidosis Icelandic Type

  • Cystatin C Amyloidosis

  • Hccaa

  • Hchwai

  • Hchwa-I

  • Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

  • Cerebral Amyloid Angiopathy Familial

  • Angiopathy, Amyloid, Cerebral, Cst3-Related

  • Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

  • Familial Cerebral Amyloid Angiopathy

  • Cerebral Amyloid Angiopathy, Hereditary
Papillon-Lefevre Syndrome

  • Papillon-Lefevre Disease

  • Papillon-Lefèvre Syndrome

  • PLS

  • Keratosis Palmoplantaris With Periodontopathia

  • PALS

  • Papillon Lefevre Syndrome

  • Keratosis Palmoplantar-Periodontopathy Syndrome

  • Papillon-Lefvre Syndrome

  • Hyperkeratosis Palmoplantaris With Periodontosis

  • Keratoris Palmoplantaris With Periodontopathia

  • Keratosis Palmoplantar - Periodontopathy

  • Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction

  • Palmoplantar Keratoderma With Periodontosis

  • Palsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03268 CST7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18469 Cst7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24950 Cst7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CST7 MGD MGI:1298217
Bos taurus CST7 VGNC VGNC:27777
Rattus norvegicus CST7 RGD RGD:1309154
Felis catus CST7 VGNC VGNC:61237
Canis familiaris CST7 VGNC VGNC:39679
Macaca mulatta CST7 VGNC VGNC:71532
Others CST7 NCBI