ICI 162846
ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU.
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- CAS. Nr.: 84545-30-2
- Formel: C11H17F3N6O
- Molecular Weight:306.29
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Alle Histamine Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
H2 Receptor |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CFLP mice were irradiated to the lower mediastinum to induce CDU[2].
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Dosage:10 mg/kg, twice daily for 5 days
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Administration:Oral gavage (p.o.)
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Result:Reduced the incidence of CDU.
Inhibited gastric acid secretion about 50% or more in the basal and the stimulated periods.
Induced massive rises in basal (12-fold) and stimulated (9-fold) luminal histamine.
Chemical Information
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CAS. Nr. 84545-30-2
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Molecular Weight 306.29
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Formel C11H17F3N6O
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SMILES
O=C(N)CCCCN1N=C(NC(NCC(F)(F)F)=N)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Wilson JA, et al. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21(6):685-9. [Content Brief]
[2]. Gompertz RH, et al. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions. 1991 May;33(1-2):161-3. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ICI 162846 Related Classifications
HY-101234 Related Classifications
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