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Art. -Nr.: HY-110133A

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JTE-607 free base

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

JTE-607 free base, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 free base inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 free base.

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CAS. Nr.: 188791-71-1
Formel: C₂₅H₃₁Cl₂N₃O₅
Molecular Weight:524.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

JTE-607 free base Chemical Structure

CAS. Nr.: 188791-71-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

JTE-607 free base, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 free base inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively^[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 free base^[2].

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Chemical Information

CAS. Nr. 188791-71-1
Molecular Weight 524.44
Formel C₂₅H₃₁Cl₂N₃O₅
SMILES

O=C([C@@H](NC(C1=CC(Cl)=C(C(Cl)=C1O)OCCN2CCN(CC2)C)=O)CC3=CC=CC=C3)OCC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

All Flow CytometryIn Vivo Efficacy StudyIHC

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Journal Impact Factor

Acta Pharm Sin B

DeepICER: A deep learning framework for predicting compound-induced gene expression profiles. [Abstract]

2026 May;16(5):2947-2963. PMID: 42180546
Acta Pharm Sin B

2026 Feb.
Nucleic Acids Res

Transcription termination counteracts DNA damage after WEE1 inhibition. [Abstract]

2026 Jan 22;54(3):gkaf1487. PMID: 41569153

JTE-607 free base purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2026 Jan 22;54(3):gkaf1487. [Abstract]

Flow cytometry analysis of HeLa cells without (-) or with the indicated concentrations of JTE-607 (500 nM) and adavosertib (AZD1775) for 24 h. Numbers indicate γH2AX-positive cells.

JTE-607 free base purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2026 Jan 22;54(3):gkaf1487. [Abstract]

Flow cytometry analysis of pRNAPII S2 levels on chromatin in HeLa cells without (-) or with 1 μM JTE-607 for 2, 6, and 24 h (orange color).
Cell Discov

RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation. [Abstract]

2024 Mar 19;10(1):32. PMID: 38503731

JTE-607 free base purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32. [Abstract]

JTE-607 (7.143 μg per day per mouse; ICV) NSG immunocompromised mice suppressed tumor growth and prolonged mouse survival.

JTE-607 free base purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32. [Abstract]

JTE-607 (7.143 μg per day per mouse; ICV) in NSG immunocompromised mice suppressed tumor growth and prolonged mouse survival.

JTE-607 free base purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32. [Abstract]

JTE-607 (7.143 μg per day per mouse; ICV) in NSG immunocompromised mice induced tumor cell apoptosis, as measured by the TUNEL assay.
Cancer Lett

CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression. [Abstract]

2024 Jul 1:593:216925. PMID: 38718887
Cell Rep

CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells. [Abstract]

2025 Jan 22;44(1):115211. PMID: 39847481

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. M Kakutani, et al. JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm Res. 1999 Aug;48(8):461-8. [Content Brief]

[2]. Nathan T Ross, et al. CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma. Nat Chem Biol. 2020 Jan;16(1):50-59. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

JTE-607 free base

6 Cited Publications

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Biologische Aktivität
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Chemical Information
Publications (6)
Reinheit & Dokumentation
Verweise

1/16
1/16

JTE-607 free base purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2026 Jan 22;54(3):gkaf1487. [Abstract]

Customer Validation
Flow cytometry analysis of HeLa cells without (-) or with the indicated concentrations of JTE-607 (500 nM) and adavosertib (AZD1775) for 24 h. Numbers indicate γH2AX-positive cells.
1/16

JTE-607 free base purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2026 Jan 22;54(3):gkaf1487. [Abstract]

Customer Validation
Flow cytometry analysis of pRNAPII S2 levels on chromatin in HeLa cells without (-) or with 1 μM JTE-607 for 2, 6, and 24 h (orange color).
1/16

JTE-607 free base purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32. [Abstract]

Customer Validation
JTE-607 (7.143 μg per day per mouse; ICV) NSG immunocompromised mice suppressed tumor growth and prolonged mouse survival.
1/16

JTE-607 free base purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32. [Abstract]

Customer Validation
JTE-607 (7.143 μg per day per mouse; ICV) in NSG immunocompromised mice suppressed tumor growth and prolonged mouse survival.
1/16

JTE-607 free base purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32. [Abstract]

Customer Validation
JTE-607 (7.143 μg per day per mouse; ICV) in NSG immunocompromised mice induced tumor cell apoptosis, as measured by the TUNEL assay.

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JTE-607 free base

Publications Citing Use of MedChemExpress (MCE) JTE-607 free base

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (6)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

JTE-607 free base Related Classifications

HY-110133A Related Classifications