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Art. -Nr.: HY-181072

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POLRMT-IN-4

POLRMT-IN-4 is a photoactivated mitochondrial RNA polymerase (POLRMT) inhibitor. POLRMT-IN-4 can be liberated from the photoactivatable prodrug upon irradiation, enables spatiotemporally precise inhibition and localized tissue selectivity. POLRMT-IN-4 disrupts mitochondrial transcription, impairs oxidative phosphorylation, and suppresses cancer cell proliferation. POLRMT-IN-4 can be used in research on various cancers, such as pancreatic cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₃H₂₃FN₂O₄
Molecular Weight:410.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

POLRMT-IN-4 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

RNA Polymerase

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

POLRMT-IN-4 (LJ03) (168 h) inhibits the proliferation of MIA PaCa-2 pancreatic cancer cells with an IC₅₀ of 0.127 μM and HEK293T normal cells with an IC₅₀ of 0.327 μM^[1].
POLRMT-IN-4 (LJ03) (500 nM; 12 h) reduces the mitochondrial ND1 transcript level in MIA PaCa-2 cells to 22.2% of control and in HEK293T cells to 39.9% of control^[1].
POLRMT-IN-4 (LJ03) (25-100 nM; 14 days) significantly suppresses colony formation of MIA PaCa-2 cells^[1].
POLRMT-IN-4 (LJ03) (500 nM; 96 h) does not perturb cell cycle progression in MIA PaCa-2 cells^[1].
POLRMT-IN-4 (LJ03) (500 nM; 96 h) does not trigger apoptotic pathways in MIA PaCa-2 cells^[1].
POLRMT-IN-4 (LJ03) (168 h) exhibits broad-spectrum antiproliferative activity against multiple cancer cell lines (A2780, HeLa, A431, MDA-MB-468, HepG2) with activity unaffected by irradiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MIA PaCa-2 cells
Concentration:

500 nM
Incubation Time:

96 h
Result:

Did not cause significant changes in the distribution of MIA PaCa-2 cells across G1, S, and G2 phases after 96 h of incubation in the dark or upon light irradiation.

Apoptosis Analysis^[1]

Cell Line:

MIA PaCa-2 cells
Concentration:

500 nM
Incubation Time:

96 h
Result:

Did not induce significant early or late apoptotic markers in MIA PaCa-2 cells after 96 h of incubation in the dark or upon light irradiation.

In Vivo

POLRMT-IN-4 (LJ03) (500 nM; aquatic exposure; 3 days) exhibits significant tumor growth inhibition in a zebrafish pancreatic cancer xenograft model under dark conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Zebrafish (Danio rerio, AB strain) bearing MIA PaCa-2 cells.^[1]
Dosage:

500 nM
Administration:

Aqueous exposure; 3 days
Result:

Significantly suppressed tumor-associated fluorescence intensity.

Chemical Information

Molecular Weight 410.44
Formel C₂₃H₂₃FN₂O₄
SMILES

O=C1C=C(C2=CC=CC=C2C)C3=C(O1)C=C(O[C@H](C)C(N4CCNCC4)=O)C(F)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Huang L, et al. A photoactivatable prodrug strategy toward spatially targeted inhibition of POLRMT for anticancer therapy. Eur J Med Chem. 2026;304:118537. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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POLRMT-IN-4

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

POLRMT-IN-4 Related Classifications

HY-181072 Related Classifications