ABC1
The ABC1 group, also known as the ADCK or COQ8 family, contains atypical protein kinases whose catalytic domains resemble prokaryotic kinases more than the canonical human eukaryotic protein kinase fold. Mammalian members include ADCK1, ADCK2, and the coenzyme Q-binding proteins COQ8A/ADCK3 and COQ8B/ADCK4, all localized to mitochondria. COQ8A and COQ8B function within the CoQ (ubiquinone) biosynthesis complex, stabilizing and phosphorylating partners of the synthome rather than propagating classical signaling cascades, and loss-of-function mutations in COQ8A cause cerebellar ataxia while COQ8B mutations cause steroid-resistant nephrotic syndrome, both forms of primary CoQ10 deficiency that respond to CoQ supplementation. Recombinant ABC1-family proteins support studies of mitochondrial bioenergetics, atypical kinase catalysis, and CoQ-deficiency disease modeling.
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ABC1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
