Ret
The Ret family, represented in humans by a single gene, RET, encodes a receptor tyrosine kinase with a distinctive modular ectodomain: four cadherin-like repeats and a cysteine-rich region, followed by a single transmembrane helix and a cytoplasmic kinase domain. RET does not bind its GDNF-family ligands directly; instead, ligand engagement of GPI-anchored GFRα co-receptors assembles the active receptor complex. RET is essential for enteric nervous system colonization, kidney organogenesis and spermatogonial stem cell maintenance. Loss-of-function variants cause Hirschsprung disease, while activating mutations or fusions drive multiple endocrine neoplasia type 2, medullary and papillary thyroid carcinoma and lung adenocarcinoma, establishing RET as both developmental gene and clinical oncology target.
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Ret Recombinant Proteins (14)
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- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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