SCH-538415
SCH-538415 is a novel acyl carrier protein synthase inhibitor isolated from an unknown bacterial microorganism. The structural elucidation of compound 1 was completed by analyzing spectral data including UV, MS and 2D-NMR spectra. Compound 1 showed inhibitory activity in the acyl carrier protein synthase (AcpS) test with an IC50 value of 4.19 μM and exhibited antibacterial activity against Staphylococcus aureus in the agar diffusion test.
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- CAS. Nr.: 637772-75-9
- Formel: C16H14N2O4
- Molecular Weight:298.29
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | GI50 |
0.54 μg/mL
Compound: 1, SCH-538415
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Growth inhibition of human BXPC3 cells
Growth inhibition of human BXPC3 cells
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[PMID: 16724845] |
| DU-145 | GI50 |
1 μg/mL
Compound: 1, SCH-538415
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Growth inhibition of human DU145 cells
Growth inhibition of human DU145 cells
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[PMID: 16724845] |
| KM-20L2 | GI50 |
0.32 μg/mL
Compound: 1, SCH-538415
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Growth inhibition of human KM20L2 cells
Growth inhibition of human KM20L2 cells
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[PMID: 16724845] |
| MCF7 | GI50 |
0.49 μg/mL
Compound: 1, SCH-538415
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Growth inhibition of human MCF7 cells
Growth inhibition of human MCF7 cells
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[PMID: 16724845] |
| NCI-H460 | GI50 |
1.2 μg/mL
Compound: 1, SCH-538415
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Growth inhibition of human NCI-H460 cells
Growth inhibition of human NCI-H460 cells
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[PMID: 16724845] |
| P388 | GI50 |
1.4 μg/mL
Compound: 1, SCH-538415
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Growth inhibition of mouse P388 cells
Growth inhibition of mouse P388 cells
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[PMID: 16724845] |
| SF-268 | GI50 |
1.3 μg/mL
Compound: 1, SCH-538415
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Growth inhibition of human SF268 cells
Growth inhibition of human SF268 cells
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[PMID: 16724845] |
Chemical Information
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CAS. Nr. 637772-75-9
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Molecular Weight 298.29
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Formel C16H14N2O4
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SMILES
O=C1N(C2=C(C(C)=C1)C(C(C(C)=C3)=C(C2=O)N(C)C3=O)=O)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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