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Art. -Nr.: HY-18176

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SEN 78702

SEN 78702 is an orally active, selective, full α7 nAChR agonist, with a pEC₅₀ of 6.13. SEN 78702 has an acceptable hERG inhibition (IC₅₀: 15.8 μM). SEN 78702 induces memory enhancement.

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CAS. Nr.: 1205530-63-7
Formel: C₁₇H₂₂FN₅O
Molecular Weight:331.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SEN 78702 Chemical Structure

CAS. Nr.: 1205530-63-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

pEC₅₀: 6.13 (α7 nAChR); IC₅₀: 15.8 μM (hERG)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	15.8 μM Compound: 12, SEN78702, WYE-308775	Inhibition of human ERG expressed in CHO cells Inhibition of human ERG expressed in CHO cells	[PMID: 23083093]
GH4-C1	EC₅₀	0.74 μM Compound: 12, SEN78702, WYE-308775	Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells assessed as stimulation of calcium flux by FLIPR Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells assessed as stimulation of calcium flux by FLIPR	[PMID: 23083093]
GH4-C1	EC₅₀	10.7 μM Compound: 12, SEN78702, WYE-308775	Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells by patch clamp assay Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells by patch clamp assay	[PMID: 23083093]

Chemical Information

CAS. Nr. 1205530-63-7
Molecular Weight 331.39
Formel C₁₇H₂₂FN₅O
SMILES

O=C(NC1=CC(C2=CC(F)=CN=C2)=NN1)CCCN3CCCCC3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zanaletti R, et al. N-[5-(5-Fluoropyridin-3-yl)-1 H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate[J]. Journal of Medicinal Chemistry, 2012, 55(22): 10277-10281.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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