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United States

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Art. -Nr.: HY-187359

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SR-B-182

SR-B-182 is a SARS-CoV-2 main protease (M_Pro) inhibitor with an IC₅₀ of 0.015 μM. SR-B-182 can be used for the research of COVID-19.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₉H₅N₅O₃
Molecular Weight:231.17

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SR-B-182 Chemical Structure

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Preis

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Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SR-B-182 is a SARS-CoV-2 main protease (M_Pro) inhibitor with an IC₅₀ of 0.015 μM. SR-B-182 can be used for the research of COVID-19^[1].

In Vitro

SR-B-182 acts via a covalent mechanism based on nucleophilic aromatic substitution (SNAr), forming a covalent adduct with Cys145 at the catalytic site of MPro without causing steric hindrance conflict with the aa187-189 loop of MPro.^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 231.17
Formel C₉H₅N₅O₃
SMILES

O=[N+](C1=NON=C1C2=NC3=CC=CC=C3N2)[O-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Sandeep Atla, et al. High-Throughput Screening Identifies Covalent Inhibitors with Unique Chemistry and Binding Modes for SARS-CoV-2 Main Protease. JACS Au 2026.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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