TH-Z145
Based on 1 Customer Validation
TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM).
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- Reinheit: 99.69%
- CAS. Nr.: 2260887-57-6
- Formel: C16H28O7P2
- Molecular Weight:394.34
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
FPPS[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B16-OVA cells (s.c.) xenograft mice model[1].
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Dosage:20 μg
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Administration:Intraperitoneal injection (i.p.)
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Result:Inhibited tumor growth and prolonged survival.
Chemical Information
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CAS. Nr. 2260887-57-6
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Appearance Solid
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Molecular Weight 394.34
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Formel C16H28O7P2
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Color Off-white to light yellow
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SMILES
O=P(O)(C(P(O)(O)=O)CC1=CC(OCCCCCCCC)=CC=C1)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (253.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5359 mL | 12.6794 mL | 25.3588 mL | 63.3971 mL |
| 5 mM | 0.5072 mL | 2.5359 mL | 5.0718 mL | 12.6794 mL | |
| 10 mM | 0.2536 mL | 1.2679 mL | 2.5359 mL | 6.3397 mL | |
| 15 mM | 0.1691 mL | 0.8453 mL | 1.6906 mL | 4.2265 mL | |
| 20 mM | 0.1268 mL | 0.6340 mL | 1.2679 mL | 3.1699 mL | |
| 25 mM | 0.1014 mL | 0.5072 mL | 1.0144 mL | 2.5359 mL | |
| 30 mM | 0.0845 mL | 0.4226 mL | 0.8453 mL | 2.1132 mL | |
| 40 mM | 0.0634 mL | 0.3170 mL | 0.6340 mL | 1.5849 mL | |
| 50 mM | 0.0507 mL | 0.2536 mL | 0.5072 mL | 1.2679 mL | |
| 60 mM | 0.0423 mL | 0.2113 mL | 0.4226 mL | 1.0566 mL | |
| 80 mM | 0.0317 mL | 0.1585 mL | 0.3170 mL | 0.7925 mL | |
| 100 mM | 0.0254 mL | 0.1268 mL | 0.2536 mL | 0.6340 mL |
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