Asah2 - N-acylsphingosine amidohydrolase 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54447

Summary

Enables N-acylsphingosine amidohydrolase activity. Involved in lipid digestion and sphingolipid metabolic process. Located in caveola; extracellular space; and mitochondrion. Is integral component of plasma membrane. Orthologous to several human genes including ASAH2B (N-acylsphingosine amidohydrolase 2B). [provided by Alliance of Genome Resources, Apr 2022]

Asah2 Products (1)

mRNA Protein Name
NM_018830.1 NP_061300.1 neutral ceramidase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acylsphingosine amidohydrolase activity IDA
IDA: Inferred from direct assay
10652340 MGI
enables N-acylsphingosine amidohydrolase activity IMP
IMP: Inferred from mutant phenotype
21613224 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12921776 MGI
Biological Process GO Annotation Evidence References Source
involved in ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
21613224 MGI
involved in ceramide catabolic process IDA
IDA: Inferred from direct assay
10652340 MGI
involved in ceramide catabolic process IMP
IMP: Inferred from mutant phenotype
16126722 MGI
involved in lipid digestion IMP
IMP: Inferred from mutant phenotype
16380386 MGI
involved in sphingosine biosynthetic process IDA
IDA: Inferred from direct assay
10652340 MGI
involved in sphingosine biosynthetic process IMP
IMP: Inferred from mutant phenotype
16126722 MGI
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
12921776 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
16126722 MGI
located in membrane IDA
IDA: Inferred from direct assay
10753931 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
21613224 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12921776 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neutral ceramidase

  • N-CDase

  • NCDase

  • acylsphingosine deacylase 2

  • neutral/alkaline ceramidase

Recombinant Asah2 Proteins

Cat. No. Product Name Accession Purity
HY-P76735 ASAH2 Protein, Mouse (HEK293, His) Q9JHE3/NP_061300.1 (T34-T756) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01054 ASAH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19409 Asah2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25901 Asah2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asah2 NCBI NCBI:56624