AS-183
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC50=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC50 values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 147317-12-2
- Formule: C19H34O3
- Masse moléculaire:310.47
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
25.5 μM
Compound: 101; AS-183
|
Reduction in cholesteryl ester synthesis in human Caco-2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
Reduction in cholesteryl ester synthesis in human Caco-2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
|
[PMID: 36473091] |
| HepG2 | IC50 |
18.1 μM
Compound: 101; AS-183
|
Reduction in cholesteryl ester synthesis in human HepG2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
Reduction in cholesteryl ester synthesis in human HepG2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
|
[PMID: 36473091] |
| THP-1 | IC50 |
34.5 μM
Compound: 101; AS-183
|
Reduction in cholesteryl ester synthesis in human THP-1 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
Reduction in cholesteryl ester synthesis in human THP-1 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
|
[PMID: 36473091] |
Chemical Information
-
CAS No. 147317-12-2
-
Masse moléculaire 310.47
-
Formule C19H34O3
-
SMILES
O=C1C(O)(OC(C(CC(CC(CC(CC)C)C)C)C)=C1C)C
-
Structure Classification
-
Initial Source
Scedosporium sp.
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS-183 Related Classifications
HY-129340 Related Classifications
Powered by Bioz