CypD-IN-6
CypD-IN-6 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 32 nM) and binds to CypD (Kd = 60 nM). CypD-IN-6 can be used for mitochondrial permeability transition pore (MPTP) related disease research such as ischemia-reperfusion injury and acute pancreatitis1.
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- Formule: C19H22BrN5O2
- Masse moléculaire:432.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
1|
Cyclophilin D 32 nM (Ki) |
In Vitro
CypD-IN-6 (12a) (10 μM) increases mitochondrial calcium retention capacity (CRC) in isolated mouse liver mitochondria[1].
CypD-IN-6 shows no protection in mitochondria isolated from CypD knockout (Ppif-/-) mice, which is consistent with a CypD-dependent mechanism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 432.31
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Formule C19H22BrN5O2
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SMILES
NC1=CC=C(C=C1)CNC(NCC(N2N(CCC2)C3=CC=CC=C3Br)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CypD-IN-6 Related Classifications
HY-179416 Related Classifications
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