DEPTOR-IN-1
Based on 1 Customer Validation
DEPTOR-IN-1 is a novel putative DEPTOR inhibitor with a Kd value of 9.3 μM.
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- Pureté : 98.13%
- CAS No.: 2615911-12-9
- Formule: C24H16Cl2FNO4
- Masse moléculaire:472.29
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
10 μM
Compound: C3
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Antiproliferative activity against human DLD1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human DLD1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| HepG2 | IC50 |
>10 μM
Compound: C3
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| HL-60 | IC50 |
6.6 μM
Compound: C3
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Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| MCF7 | IC50 |
8.68 μM
Compound: C3
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| MGC-803 | IC50 |
>10 μM
Compound: C3
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Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| MOLT-4 | IC50 |
7.02 μM
Compound: C3
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Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| NCI-H460 | IC50 |
>10 μM
Compound: C3
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Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| RPMI-8226 | IC50 |
1.09 μM
Compound: C3
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Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| SiHa | IC50 |
>10 μM
Compound: C3
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Antiproliferative activity against human SiHa cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human SiHa cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| U-251 | IC50 |
>10 μM
Compound: C3
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Antiproliferative activity against human U251 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human U251 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| U-266 | IC50 |
1.11 μM
Compound: C3
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Antiproliferative activity against human U266 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human U266 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
| U2OS | IC50 |
>10 μM
Compound: C3
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Antiproliferative activity against human U2OS cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human U2OS cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
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[PMID: 34644502] |
Chemical Information
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CAS No. 2615911-12-9
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Appearance Solid
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Masse moléculaire 472.29
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Formule C24H16Cl2FNO4
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Color Light yellow to yellow
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SMILES
O=C1C2=CC=C3OCN(CC3=C2OC(C4=CC(Cl)=C(C=C4)Cl)=C1O)CC5=CC(F)=CC=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 4 mg/mL (8.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1173 mL | 10.5867 mL | 21.1734 mL | 52.9336 mL |
| 5 mM | 0.4235 mL | 2.1173 mL | 4.2347 mL | 10.5867 mL |
DEPTOR-IN-1 Related Classifications
HY-132902 Related Classifications
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