Disopyramide hydrochloride
Based on 3 publication(s) in Google Scholar
Disopyramide hydrochloride is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide hydrochloride blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide hydrochloride inhibits HERG encoded potassium channels. Disopyramide hydrochloride also exhibits complex protein binding, and has a potent negative inotropic action.
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- CAS No.: 54687-36-4
- Formule: C21H30ClN3O
- Masse moléculaire:375.94
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Stockage:
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Activité biologique
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Disopyramide hydrochloride
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Activité biologique
Description
In Vitro
HERG tail currents recorded at -40 mV following test pulses to +30 mV are inhibited in a dose-dependent fashion by Disopyramide hydrochloride concentrations within the clinical range (IC50=7.23 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 54687-36-4
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Masse moléculaire 375.94
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Formule C21H30ClN3O
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SMILES
NC(C(C1=CC=CC=C1)(C2=CC=CC=N2)CCN(C(C)C)C(C)C)=O.Cl
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Synonyms
Dicorantil hydrochloride; SC-7031 hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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J Med Chem
Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration. [Abstract]2021 Mar 11;64(5):2725-2738. PMID: 33619967 -
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Biochem Biophys Res Commun
Dual-cardiotoxicity evaluation of torsadogenic risk drugs using human iPSC-derived cardiomyocytes. [Abstract]2025 Oct 30:786:152756. PMID: 41043280
Pureté et documentation
Références
[1]. S V Jones, et al. Non-competitive Effects of Disopyramide at the Neuromuscular Junction: Evidence for Endplate Ion Channel Block. Br J Anaesth. 1987 Jun;59(6):776-83. [Content Brief]
[2]. L A Siddoway, et al. Clinical Pharmacokinetics of Disopyramide. Clin Pharmacokinet. May-Jun 1986;11(3):214-22. [Content Brief]
[3]. A A Paul, et al. Inhibition of HERG Potassium Channel Current by the Class 1a Antiarrhythmic Agent Disopyramide. Biochem Biophys Res Commun. 2001 Feb 9;280(5):1243-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Disopyramide hydrochloride Related Classifications
HY-12533B Related Classifications
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