Esculentic acid
Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta.
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- CAS No.: 103974-74-9
- Formule: C30H48O5
- Masse moléculaire:488.70
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
COX-2[1]
Chemical Information
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CAS No. 103974-74-9
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Masse moléculaire 488.70
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Formule C30H48O5
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SMILES
C[C@]12[C@]3(C([C@@]4([H])[C@](C(O)=O)(CC[C@@H](C)[C@@H]4C)CC3)=CC[C@]1([H])[C@@]5([C@@]([C@@](C)([C@H](O)[C@H](O)C5)CO)([H])CC2)C)C
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureté et documentation
Références
[1]. Niu X, et al. Esculentic acid, a novel and selective COX-2 inhibitor with anti-inflammatory effect in vivo and in vitro. Eur J Pharmacol. 2014 Oct 5;740:532-8. [Content Brief]
[2]. Niu X, et al. Protective effects of esculentic acid against endotoxic shock in Kunming mice. Int Immunopharmacol. 2014 Nov;23(1):229-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Esculentic acid Related Classifications
HY-N3866 Related Classifications
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