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Cat. No.: HY-182080

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EVs inducer-1

EVs inducer-1 is a release inducer of immunostimulatory extracellular vesicles (EVs). EVs inducer-1 inhibits tubulin polymerization. EVs inducer-1 enhances the release of immunostimulatory EVs by antigen-presenting cells, increases the release of EV particles from dendritic cells, and elevates CD63 reporter gene activity. EVs inducer-1 inhibits the viability of proliferating cells. EVs inducer-1 is applicable for research related to immune regulation.

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CAS No.: 710280-48-1
Formule: C₂₁H₁₃N₃OS
Masse moléculaire:355.41

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EVs inducer-1 Chemical Structure

CAS No.: 710280-48-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Bioz

Activité biologique

Description

In Vitro

EVs inducer-1 (Compound 1) (10 μM; 48 h) significantly enhances CD63-mediated EV release in human CD63 Tluc-CD9 EmGFP THP-1 reporter cells^[1].
EVs inducer-1 (10 μM; 20 h) exhibits extremely low cytotoxicity in primary mBMDC and hPBMC, but inhibits the viability of Jurkat, Ramos, RAW264.7, NIH3T3 and C2C12 cells^[1].
EVs inducer-1 (0-10 μM) dose-dependently inhibits tubulin polymerization in cell-free biochemical assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay^[1]

Cell Line:

Jurkat, Ramos, RAW264.7, NIH3T3, C2C12 cells
Concentration:

10 μM
Incubation Time:

20 h
Result:

Reduced the cells activity (10-70%).

Chemical Information

CAS No. 710280-48-1
Masse moléculaire 355.41
Formule C₂₁H₁₃N₃OS
SMILES

C1(C=CC=C2)=C2C=CC=C1C3=NN=C(C4=CC(C5=CC=CS5)=CN=C4)O3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Shukla NM, et al. Structure-Activity Relationship Studies in Substituted Oxadiazoles as Inducers of Extracellular Vesicles. J Med Chem. 2026;69(6):6490-6507. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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