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MT3 - metallothionein 3 Gene

Also Known as GIF; GIFB; GRIF; ZnMT3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4504

About MT3

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,589,528-56,591,085 (from NCBI)

This gene has 6 transcripts (splice variants), 188 orthologues and 11 paralogues. Biased expression in brain (RPKM 149.3) and adrenal (RPKM 10.1).

Summary

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by Other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017]

MT3 Products (1)

mRNA	Protein	Name
NM_005954.4	NP_005945.1	metallothionein-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables cadmium ion binding	IDA IDA: Inferred from direct assay	16601975	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	21320589	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20646067	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	18295594	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	17712581	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in activation of protein kinase B activity	IDA IDA: Inferred from direct assay	18295594	GOA
involved in cellular detoxification	IDA IDA: Inferred from direct assay	18554677	GOA
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	18206644	GOA
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	20039155	GOA
involved in cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	18554677	GOA
involved in negative regulation of axon extension	IDA IDA: Inferred from direct assay	16601975	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	16601975	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	16945328	GOA
involved in negative regulation of oxidoreductase activity	IDA IDA: Inferred from direct assay	21320589	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18295594	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18295594	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18295594	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	18295594	GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	18295594	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	18295594	GOA
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	12383939	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	12763630	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10355541	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	20039155	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20039155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT3 Protein Structure

Metallothio

0
68 a.a.

Protein Preferred Names	Protein Names
metallothionein-3	growth inhibitory factor

MT3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	MT3	P25713	TTR	Homo sapiens	P02766	Anti Tag CoIP	20646067
Intra	MT3	P25713	TTR	Homo sapiens	P02766	Saturation Binding	20646067
Intra	MT3	P25713	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Milker'S Nodule	Poxviridae Infections Milker Nodule Milkers' Node Paravaccinia Pseudocowpox Milker'S Nodes
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Menkes Disease	Copper Transport Disease Menkes Syndrome MNK Kinky Hair Disease Steely Hair Disease Menkes Kinky-Hair Syndrome Mk Steely Hair Syndrome Menkea Syndrome Md Menkes Kinky Hair Syndrome Hypocupremia, Congenital Kinky Hair Syndrome X-Linked Copper Deficiency Menkes Kinky Hair Disease
Deficiency Anemia	Anemia Deficiency Anemias Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-128206	I3MT-3	Inhibitor	99.76%	Unkown
HY-P5846	Muscarinic toxin 3	Antagonist	/	Unkown
HY-RS08744	MT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19565	Mt3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26061	Mt3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MT3	RGD	RGD:621252
Mus musculus	MT3	MGD	MGI:97173
Bos taurus	MT3	VGNC	VGNC:52208
Others	MT3	NCBI