OSM - oncostatin M Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5008

About OSM

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,262,829-30,266,851 (from NCBI)

This gene has 3 transcripts (splice variants) and 77 orthologues. Biased expression in bone marrow (RPKM 29.4), appendix (RPKM 5.8) and 4 other tissues.

Summary

This gene encodes a member of the Leukemia Inhibitory Factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of Other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, Leukemia Inhibitory Factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

OSM Products (2)

mRNA	Protein	Name
NM_001319108.2	NP_001306037.1	oncostatin-M isoform 2
NM_020530.6	NP_065391.1	oncostatin-M isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	8999038	GOA
enables growth factor activity	IDA IDA: Inferred from direct assay	8999038	GOA
enables oncostatin-M receptor binding	IPI IPI: Inferred from physical interaction	8999038	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16051226	GOA

Biological Process GO Annotation	Evidence	Références	Source
acts upstream of or within negative regulation of hormone secretion	IDA IDA: Inferred from direct assay	7867561	GOA
involved in oncostatin-M-mediated signaling pathway	IDA IDA: Inferred from direct assay	8999038	GOA
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	7508917	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8999038	GOA
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	28972028	GOA
acts upstream of positive regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	28972028	GOA
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	7508917	GOA
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7508917	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8999038	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	28972028	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7508917	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	21912637	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSM Protein Structure

LIF_OSM

0
100
200
252 a.a.

Protein Preferred Names	Protein Names
oncostatin-M

OSM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	OSM	P13725	IL6ST	Homo sapiens	P40189	Anti Tag CoIP	33961781
Intra	OSM	P13725	IL6ST	Homo sapiens	P40189	Pull Down	16051226
Intra	OSM	P13725	IL6ST	Homo sapiens	P40189	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OSM Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P7052	OSM Protein, Human (227a.a)	P13725 (A26-R252)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7052A	OSM Protein, Human (209a.a)	P13725 (A26-R234)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70465	OSM Protein, Human (His)	P13725 (A26-R221)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73331	OSM Protein, Human (HEK293, His)	P13725 (A26-R221)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74662	OSM Protein, Human (HEK293)	P13725 (A26-R221)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78187	OSM Protein, Human (Biotinylated, HEK293, His-Avi)	P13725 (A26-R221)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78502	OSM Protein, Human (HEK293, His-Avi)	P13725 (A26-R221)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P7052B	OSM Protein, Human (227a.a, His)	P13725 (A26-R252)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70465G	GMP OSM Protein, Human (His)	P13725 (A26-R221)	≥ 95%, as determined by reducing SDS-PAGE.

OSM Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P83068	Oncostatin M Antibody (YA2813)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Plasmacytoma	Solitary Plasmacytoma Solitary Myeloma Myeloma - Solitary Myeloma, Solitary Plasmacytoma - Category Solitary Osseous Plasmacytoma Solitary Plasmacytoma Without Mention Of Remission Localised Malignant Plasma Cell Tumour Nos Plasmacytoma Nos
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Arthrogryposis, Distal, Type 1a	Distal Arthrogryposis Type 1 Digitotalar Dysmorphism DA1A Da1 Amcd1 Arthrogryposis, Distal, Type 2b4 Distal Arthrogryposis Type 1a Arthrogryposis, Distal, Type 1 Arthrogryposis Multiplex Congenita Distal Type 1 Arthrogryposis Multiplex Congenita, Distal Type 1 Arthrogryposis Multiplex Congenita, Distal, Type I Distal Arthrogryposis Type 1b Arthrogryposis, Distal, 1a Amc Arthrogryposis Multiplex Congenita Arthrogryposis, Distal, 2b4 DA2B4 Arthrogryposis Multiplex Congenita, Distal, Type 1 Arthrogryposis
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Sialadenitis	Sialoadenitis Adenitis, Salivary Gland Salivary Gland Inflammation Salivary Gland Adenitis Sialitis Inflammation Of Salivary Gland Inflammation Of Salivary Duct Or Gland Salivary Glandular Adenitis Sialoangiitis Sialoangitis Sialodochitis
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Crisponi/Cold-Induced Sweating Syndrome 2	Cold-Induced Sweating Syndrome 2 CISS2 Sweating Syndrome, Cold-Induced, Type 2
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Sodoku Disease	Spirillosis Sodoku Spirillary Fever Rat-Bite Fever Rat-Bite Fever Due To Spirillum Minus Spirillary Rat-Bite Fever Sokosho
Psoriasis
Amelanotic Melanoma	Melanoma, Amelanotic Melanoma Amelanotic Amelanotic Skin Melanoma
Arthropathy	Ankylosis Of Ankle And Foot Joint Ankylosis Of Forearm Joint Ankylosis Of Hand Joint Ankylosis Of Joint Of Ankle And/Or Foot Ankylosis Of Joint Of Forearm Ankylosis Of Joint Of Hand Ankylosis Of Joint Of Lower Leg Ankylosis Of Joint Of Multiple Sites Ankylosis Of Joint Of Pelvic Region And Thigh Ankylosis Of Joint Of Shoulder Region Ankylosis Of Joint Of Upper Arm Ankylosis Of Lower Leg Joint Ankylosis Of Multiple Joints Ankylosis Of Upper Arm Joint Infectious Arthropathy Joint Ankylosis Of The Ankle And Foot Joint Ankylosis Of The Ankle And/Or Foot Joint Ankylosis Of The Forearm Joint Ankylosis Of The Hand Joint Ankylosis Of The Lower Leg Joint Ankylosis Of The Pelvic Region And Thigh Joint Ankylosis Of The Shoulder Region Joint Ankylosis Of The Upper Arm Joint Diseases Joint Disease Arthropathy Associated With Infection
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis
Crigler-Najjar Syndrome, Type I	Crigler-Najjar Syndrome Crigler-Najjar Syndrome Type 1 Bilirubin Udp Glucuronyl Transferase Deficiency Crigler Najjar Syndrome Crigler Najjar Syndrome, Type 1 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Bilirubin-Ugt Deficiency Hyperbilirubinemia, Crigler-Najjar Type I Hblrcn1 Familial Nonhemolytic Unconjugated Hyperbilirubinemia Hereditary Unconjugated Hyperbilirubinemia Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1 Bilirubin-Ugt Deficiency Type 1 Crigler-Najjar Syndrome 1 CN1 Cn-I Crigler-Najjar Syndrome Type I Hereditary Unconjugated Hyperbilirubinaemia Ugt Deficiency Bilirubin Glucuronosyltransferase Deficiency Crigler-Najjar Disease Or Syndrome Deficiency Of Glucuronosyltransferase Glucuronyl Transferase Deficiency Glucuronyltransferase Deficiency Udp Glucuronyl Transferase Deficiency Cns - [Crigler-Najjar Syndrome] Congenital Familial Nonhemolytic Jaundice
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P99590	Sotatercept		99.94%	Unkown

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P99519	Vixarelimab	Inhibitor	96.90%	Phase 2
HY-P991051	GSK-2330811	Inhibitor	98.69%	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-33354	Nitrochin		99.92%	Unkown
HY-148692	OSM-SMI-10B	Inhibitor	99.70%	Unkown
HY-175465	SMI-10B13	Inhibitor	99.30%	Unkown
HY-162238	OSM-S-106	Inhibitor	99.34%	Unkown
HY-148693	OSM-SMI-8	Antagonist	/	Unkown
HY-148693A	(E/Z)-OSM-SMI-8	Antagonist	/	Unkown
HY-148692A	(E/Z)-OSM-SMI-10B	Inhibitor	/	Unkown
HY-148695B	ADR58 sodium	Inhibitor	/	Unkown
HY-148695C	Truncated ADR58 sodium	Inhibitor	/	Unkown
HY-RS02108	CCM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09850	OSM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16547	Osm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22979	Osm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P991333	GSK-315234	Inhibitor	98.16%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	OSM	RGD	RGD:1585012
Felis catus	OSM	VGNC	VGNC:68658
Macaca mulatta	OSM	VGNC	VGNC:75720
Canis familiaris	OSM	VGNC	VGNC:44166
Bos taurus	OSM	VGNC	VGNC:32474
Mus musculus	OSM	MGD	MGI:104749
Others	OSM	NCBI