CABP1 - calcium binding protein 1 Gene

Also Known as CALBRAIN; HCALB_BR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9478

About CABP1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,640,626-120,680,866 (from NCBI)

This gene has 5 transcripts (splice variants), 292 orthologues and 20 paralogues. Biased expression in brain (RPKM 5.5), fat (RPKM 2.2) and 5 other tissues.

Summary

Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to Calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]

CABP1 Products (3)

mRNA	Protein	Name
NM_001033677.2	NP_001028849.1	calcium-binding protein 1 isoform 3
NM_004276.5	NP_004267.2	calcium-binding protein 1 isoform 2
NM_031205.4	NP_112482.1	calcium-binding protein 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	15980432	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11865310	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	19338761	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19338761	GOA
located in postsynaptic density	IDA IDA: Inferred from direct assay	15140941	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CABP1 Protein Structure

EF-hand_1

EF-hand_7

0
100
200
300
370 a.a.

Protein Preferred Names	Protein Names
calcium-binding protein 1	calcium binding protein 5

CABP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CABP1	Q9NZU7	CACNA1C	Homo sapiens	Q13936	Pull Down	15140941

Cross: Cross-species interaction Intra: Intraspecies interaction

CABP1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P86797	CABP1 Antibody (YA6490)	WB, FC	Human

Related Diseases

Diseases	Alias
Spinal Cord Lymphoma	Lymphoma Of The Spinal Cord Spinal Cord Cancer Spine Lymphoma Spinal Cord--Cancer
Drug Psychosis	Drug-Induced Psychosis Drug-Induced Psychotic Disorder Psychoses, Substance-Induced Psychoses, Drug
Drug-Induced Mental Disorder
Tinea Nigra	Microsporosis Nigra Infection By Cladosporium Werneckii Keratomycosis Nigricans Tinea Palmaris Nigra Keratomycosis Nigricans Palmaris
Corneal Dystrophy, Posterior Amorphous	Posterior Amorphous Corneal Dystrophy PACD Chromosome 12q21.33 Deletion Syndrome Posterior Amorphous Stromal Dystrophy
Substance-Induced Psychosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-14737A	Ceftaroline fosamil hydrate	Inhibitor	98.88%	Yes

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-D0987	Stains-All		99.91%	Unkown
HY-RS01783	CABP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12388	S100G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24461	Pdia6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CABP1	VGNC	VGNC:60285
Bos taurus	CABP1	VGNC	VGNC:53893
Rattus norvegicus	CABP1	RGD	RGD:620385
Macaca mulatta	CABP1	VGNC	VGNC:70495
Mus musculus	CABP1	MGD	MGI:1352750
Canis familiaris	CABP1	VGNC	VGNC:106592
Others	CABP1	NCBI