ID110460001
ID110460001 is a full agonist of μ-opioid receptor and an agonist of δ-opioid receptor. ID110460001 exhibits high intrinsic efficacy for G protein pathway activation of μ-opioid receptor, and this property is not affected by the reduction in receptor quantity. ID110460001 acts only as a very weak partial agonist in the β-arrestin-2 pathway of both receptors, and binds to μ-opioid receptor via a specific mode. The efficacy of ID110460001 in the G protein pathway of δ-opioid receptor is sensitive to changes in receptor quantity. ID110460001 can be used in pain-related research.
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- CAS No.: 1110883-26-5
- Formule: C20H24N2O3
- Masse moléculaire:340.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Voir tous les produits spécifiques à Isoform Opioid Receptor
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Activité biologique
Description
IC50 & Target
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μ Opioid Receptor/MOR |
δ Opioid Receptor/DOR |
Arrestin-2/β-Arrestin 1 |
In Vitro
ID110460001 (eight-point concentration gradients; 20 min pre-incubation with irreversible antagonists) acts as a full agonist for the G protein pathway and a very weak partial agonist for the β-arrestin-2 pathway at both OPRM-overexpressing and OPRD-overexpressing HEK-293 cells, with high intrinsic efficacy at OPRM as demonstrated by maintained Emax under reduced receptor population conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1110883-26-5
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Masse moléculaire 340.42
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Formule C20H24N2O3
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SMILES
O=C(NCC(C=1C=CC=CC1)N(C)C)CC2=CC=C3OCCOC3=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ID110460001 Related Classifications
HY-W399025 Related Classifications
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