KF-22
KF-22 is an antimicrobial peptide that exhibits antimicrobial activity against both Gram-negative and Gram-positive bacteria. KF-22 demonstrates broad-spectrum, potent activity against multidrug-resistant bacteria with low toxicity. KF-22 can be used in research related to infections.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C137H229N41O27
- Masse moléculaire:2882.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
KF-22 (18-24 h) exhibits potent broad-spectrum antibacterial activity against 21 multidrug-resistant Gram-negative and Gram-positive bacteria, with MIC values ranging from 1.25 to 5 μg/mL[1].
KF-22 (0-320 μg/mL; 1-24 h) exhibits low hemolytic activity against mouse red blood cells, moderate cytotoxicity against HEK 293 cells at concentrations >120 μg/mL, and lower cytotoxicity against RAW 264.7 cells [1].
KF-22 (1-10 μg/mL) disrupts the cytoplasmic membrane potential of A. baumannii ATCC 19606 and S. aureus ATCC 25923 in a concentration-dependent manner[1].
KF-22 (0-20 μg/mL; 1 h) disrupts the outer and cytoplasmic membranes of A. baumannii ATCC 19606 and S. aureus ATCC 25923 in a dose-dependent manner[1].
KF-22 (0-20 μg/mL; 24 h) dose-dependently inhibits biofilm formation by A. baumannii ATCC 19606 and S. aureus ATCC 25923 and clears preformed biofilms[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
KF-22 (2-8 mg/kg; i.p.; single dose 1 hour post-infection) has antibacterial activity in neutropenic mice infected with A. baumannii ATCC 19606[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice (female, 6-8 weeks old, 18 ± 2 g, intraperitoneally infected with A. baumannii ATCC 19606)[1]
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Dosage:5 mg/kg; 10 mg/kg
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Administration:i.p.; daily; 3 days
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Result:Achieved 62.5% survival rate over 7 days at 5 mg/kg.
Achieved 75% survival rate over 7 days at 10 mg/kg.
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Animal Model:C57BL/6J mice (female, 6-8 weeks old, 18 ± 2 g, neutropenia induced by cyclophosphamide (HY-17420), then intraperitoneally infected with Acinetobacter baumannii ATCC 19606)[1]
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Dosage:2 mg/kg; 4 mg/kg; 8 mg/kg
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Administration:i.p.; single dose 1 hour post-infection
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Result:Reduced bacterial load in kidney, liver, lung, and spleen.
Significantly decreased proinflammatory cytokine (TNF-α, IL-1β) production in kidney and lung homogenates.
Showed no significant pathological changes in kidney, liver, lung, or spleen via H&E staining.
Chemical Information
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Masse moléculaire 2882.54
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Formule C137H229N41O27
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Sequence
Lys-Phe-Phe-Arg-Lys-Leu-Lys-Lys-Ser-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg
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Sequence Shortening
KFFRKLKKSFKRIVQRIKDFLR
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KF-22 Related Classifications
HY-P11634 Related Classifications
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