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Oleclumab

(Synonyms: MEDI9447)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity.

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  • Pureté: 99.90%
  • CAS No.: 1803176-05-7
  • Masse moléculaire:143.14 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Oleclumab
  • Experimental Validation Results for Oleclumab
  • Experimental Validation Results for Oleclumab
  • Oleclumab Chemical Structure
    Oleclumab Chemical Structure
CAS No.: 1803176-05-7
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Assay Types
  • 1/16

    Human IgG1 lambda

  • 1/16

    Immobilized CD73/5'-Nucleotidase Protein, Human (HEK293, His, HY-P70010) can bind Oleclumab. The EC50 for this effect is 3.27 ng/mL.

  • 1/16

    Flow Cytometry analysis of A431 cells labelling NT5E/CD73 (red) with Oleclumab (anti-NT5E/CD73) (HY-P99039). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 lambda2 (HY-P990096). Black-Unlabelled control, cells without incubation with primary antibody.

  • Oleclumab Chemical Structure
    1/16
  • Oleclumab
  • Immobilized CD73/5'-Nucleotidase Protein, Human (HEK293, His, HY-P70010) can bind Oleclumab. The EC50 for this effect is 3.27 ng/mL.
  • Flow Cytometry analysis of A431 cells labelling NT5E/CD73 (red) with Oleclumab (anti-NT5E/CD73) (HY-P99039). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 lambda2 (HY-P990096). Black-Unlabelled control, cells without incubation with primary antibody.