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Cat. No.: HY-169993A

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Pevifoscorvir

Name: Pevifoscorvir
Brand: MedChemExpress
SKU: HY-169993A
Availability: PreOrder

(Synonyms: ALG-000184 free acid)

Pevifoscorvir (ALG-000184 (free acid)) is an orally active inhibitor of hepatitis B virus (HBV), and it is also a prodrug of ALG-001075 (HY-177022). Pevifoscorvir can inhibit the production of HBV DNA in liver cells. Pevifoscorvir can be used in the research of chronic hepatitis B.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2495324-71-3
Formule: C₂₃H₂₂FN₄O₈P
Masse moléculaire:532.41

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pevifoscorvir Chemical Structure

CAS No.: 2495324-71-3

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

In Vitro

Pevifoscorvir (ALG-000184 (free acid)) (3 days) can effectively inhibit the production of HBV DNA in HepG2.117 cells, with its EC₅₀ being 1.45 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Pevifoscorvir (ALG-000184 (free acid)) (10-30 mg/kg; p.o.; single dose) when administered orally to rats and dogs, will be completely converted into ALG-001075, resulting in a higher exposure of ALG-001075 in the liver and a 50 or 12-fold higher systemic exposure of ALG-001075 compared to direct administration of ALG-001075^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2495324-71-3
Masse moléculaire 532.41
Formule C₂₃H₂₂FN₄O₈P
SMILES

N#CC1=CC(NC(C2=C(C)C(C(C(N(C3(COC3)C#C)COP(O)(O)=O)=O)=O)=C(C)N2C)=O)=CC=C1F
Synonyms

ALG-000184 free acid
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Sandrine Vendeville, et al. The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075. J Med Chem. 2024 Dec 12;67(23):21126-21142. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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