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Cat. No.: HY-162847

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S24–14

S24–14 is a potent antiosteoporosis agent. S24–14 inhibits osteoclastogenesis with an IC₅₀ value of 0.40 µM. S24–14 induces osteoblast differentiation. S24–14 suppresses bone loss.

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CAS No.: 2348566-35-6
Formule: C₁₉H₁₂N₂O₃S
Masse moléculaire:348.38

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

S24–14 Chemical Structure

CAS No.: 2348566-35-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

S24–14 is a potent antiosteoporosis agent. S24–14 inhibits osteoclastogenesis with an IC₅₀ value of 0.40 µM. S24–14 induces osteoblast differentiation. S24–14 suppresses bone loss^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	IC₅₀	0.4 μM Compound: S24-14	Anti-osteoclastogenic activity in M-CSF/RANKL-induced C57BL/6 mouse BMDM cells assessed as inhibition of M-CSF/RANKL-stimulated osteoclast differentiation measured after 5 days by TRAP staining based microscopic analysis Anti-osteoclastogenic activity in M-CSF/RANKL-induced C57BL/6 mouse BMDM cells assessed as inhibition of M-CSF/RANKL-stimulated osteoclast differentiation measured after 5 days by TRAP staining based microscopic analysis	[PMID: 39167391]
RAW264.7	CC₅₀	65.46 μM Compound: S24-14	Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by CCK-8 assay Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by CCK-8 assay	[PMID: 39167391]

Chemical Information

CAS No. 2348566-35-6
Masse moléculaire 348.38
Formule C₁₉H₁₂N₂O₃S
SMILES

O=C(C1=C(C=C2C(C=CC=C2)=C1)C(NC3=NC4=CC=CC=C4S3)=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Huang D, et al. Discovery of Novel Antiosteoporosis Leads with Bone Resorption Inhibition and Anabolic Promotion through a Chemotype-Assembly Approach. J Med Chem. 2024 Sep 12;67(17):15311-15327. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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