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Cat. No.: HY-P991937

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SOL-116

SOL-116 is a humanized anti-BSSL antibody. SOL-116 blocks BSSL from binding to monocytes. SOL-116 reduces the severity of Pristane (HY-N7819)-induced arthritis in rats.

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Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (258 KB)

SOL-116 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Essai clinique
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

SOL-116 is a humanized anti-BSSL antibody. SOL-116 blocks BSSL from binding to monocytes. SOL-116 reduces the severity of Pristane (HY-N7819)-induced arthritis in rats^[1].

Species Reactivity

Human

IC₅₀ & Target^[1]

Bile salt-stimulated lipase (BSSL)

In Vitro

SOL-116 binds to human, mouse, and rat BSSL with approximately 80-fold lower affinity to rodent BSSL than to human BSSL due to a single amino acid epitope deviation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SOL-116 (10-90 mg/kg; s.c.; on day 5, 10 and 15 after disease induction) reduces disease severity in DA rats with Pristane (HY-N7819)-induced arthritis (with a dose response across 10, 30, and 90 mg/kg doses)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

DA rats (pristane-induced arthritis)^[1]
Dosage:

10, 30, 90 mg/kg
Administration:

s.c.; on day 5, 10 and 15 after disease induction
Result:

Significantly mitigated disease severity at 90 mg/kg; showed decreases in disease severity at 10 mg/kg and 30 mg/kg (dose response, not statistically significant); correlated plasma concentration at day 19 significantly to the arthritis score

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

682 [NCBI]

Accession

P35613

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Lindquist S, et al. POS0434 A NOVEL TARGET FOR TREATMENT OF INFLAMMATORY JOINT DISEASES[J]. Annals of the Rheumatic Diseases, 2022, 81: 471-472.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Essai clinique
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

SOL-116

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SOL-116 Related Classifications

HY-P991937 Related Classifications