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Cat. No.: HY-N14056

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Chrolactomycin

Chrolactomycin is found in the strain of Streptomyces sp. 569N-3. The IC₅₀ of Chrolactomycin for ACHN, A431, McF-7 and T24 cells are 1.2 μM, 1.6 μM, 0.69 μM and 0.45 μM, respectively. Chrolactomycin has only anti-Gram-positive bacteria activity with the MIC of 5.2-10.4 μg/mL.

For research use only. We do not sell to patients.

CAS No.: 227606-82-8
Formula: C₂₄H₃₂O₇
Molecular Weight:432.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Chrolactomycin Chemical Structure

CAS No.: 227606-82-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.5 μM Compound: 10	Inhibition of human telomerase isolated from human A431 cellular extracts after 30 mins by TRAP assay Inhibition of human telomerase isolated from human A431 cellular extracts after 30 mins by TRAP assay	[PMID: 24053596]
A-431	IC₅₀	0.5 μM Compound: Chrolactomycin	Inhibition of telomerase extracted from human A431 cells after 30 mins by TRAP assay Inhibition of telomerase extracted from human A431 cells after 30 mins by TRAP assay	10.1039/C0MD00241K

Chemical Information

CAS No. 227606-82-8
Molecular Weight 432.51
Formula C₂₄H₃₂O₇
SMILES

CO[C@@]12[C@]3([H])[C@@]4(OC2=O)[C@](CCC[C@H](C[C@H]([C@@](C(C1=O)=C)([H])O3)C)C)([H])C=C([C@H](C4)C)C(O)=O
Structure Classification
- Others
Initial Source
- Microorganisms
Streptomyces
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. R Nakai, et al. Chrolactomycin, a novel antitumor antibiotic produced by Streptomyces sp. J Antibiot (Tokyo). 2001 Oct;54(10):836-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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