1. MAPK/ERK Pathway
  2. MEK
  3. Cobimetinib (R-enantiomer)

Cobimetinib (R-enantiomer) (Synonyms: GDC-0973 R-enantiomer; XL-518 R-enantiomer)

Cat. No.: HY-13079
Handling Instructions

Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.

For research use only. We do not sell to patients.

Cobimetinib (R-enantiomer) Chemical Structure

Cobimetinib (R-enantiomer) Chemical Structure

CAS No. : 934660-94-3

Size Price Stock
10 mM * 1  mL in DMSO USD 1403 Ask For Quote & Lead Time
5 mg USD 1200 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Other In-stock Forms of Cobimetinib (R-enantiomer):

Other Forms of Cobimetinib (R-enantiomer):

Top Publications Citing Use of Products

View All MEK Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.

Molecular Weight

531.31

Formula

C₂₁H₂₁F₃IN₃O₂

CAS No.

934660-94-3

SMILES

FC1=C(F)C=CC(C(N2CC([[email protected]]3CCCCN3)(O)C2)=O)=C1NC4=CC=C(I)C=C4F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (188.21 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8821 mL 9.4107 mL 18.8214 mL
5 mM 0.3764 mL 1.8821 mL 3.7643 mL
10 mM 0.1882 mL 0.9411 mL 1.8821 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (5.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (5.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (5.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Cobimetinib (R-enantiomer)GDC-0973 R-enantiomerXL-518 R-enantiomerMEKMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Cobimetinib (R-enantiomer)
Cat. No.:
HY-13079
Quantity:
MCE Japan Authorized Agent: