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Cat. No.: HY-188092

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Cortisol-selective aptamer

Cortisol-selective aptamer is a nucleic acid that selectively binds to cortisol. Cortisol-selective aptamer undergoes conformational transition upon binding to cortisol, inducing fluorescence quenching of quantum dots. Cortisol-selective aptamer can be integrated into gold nanoparticle colorimetric assays in buffer solutions to distinguish cortisol from other biomarkers of stress and liver dysfunction.

For research use only. We do not sell to patients.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Cortisol-selective aptamer Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

In Vitro

Cortisol-selective aptamer (Sequence 15-3, CY3 removed) exhibits only weak or non-specific binding to cortisol and progesterone in microscale thermophoresis assays^[1].
Cortisol-selective aptamer-conjugated red QD@MNP nanosensors enable efficient detection of cortisol in 0.1×10^-1 PBS buffer, with a limit of detection of approximately 1 nM^[2].
Cortisol-selective aptamer-conjugated red QD@MNP nanosensors detect cortisol in 5-fold diluted spiked saliva samples, with a limit of detection <1 nM and a linear quantification range of 0.4-400 nM; they also exhibit high selectivity for cortisol over other steroid hormones in 0.1× PBS buffer^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

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[Cortisol-selective aptamer]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (1518 KB)

References

[1]. Martin JA, et al. Tunable stringency aptamer selection and gold nanoparticle assay for detection of cortisol. Analytical and bioanalytical chemistry. 2014 Jul;406(19):4637-47.

[2]. Liu Y, et al. Label-Free Sensitive Detection of Steroid Hormone Cortisol Based on Target-Induced Fluorescence Quenching of Quantum Dots. Langmuir : the ACS journal of surfaces and colloids. 2020 Jul 14;36(27):7781-7788.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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