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Art. -Nr.: HY-189356

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COX-2-IN-70

COX-2-IN-70 is an orally active and selective COX-2 inhibitor with an IC₅₀ of 1.86 μM. COX-2-IN-70 reduces the production of prostaglandins and thromboxanes by inhibiting the COX-2 isoenzyme. COX-2-IN-70 can be used for inflammation research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₆H₁₈N₈O₈S₂
Molecular Weight:634.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

COX-2-IN-70 Chemical Structure

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Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

COX-2

1.86 μM (IC₅₀)

COX-1

8.74 μM (IC₅₀)

Alle COX Isoform-spezifische Produkte anzeigen :

In Vitro

COX-2-IN-70 (compound 10f) exhibits selective inhibition of COX-2 over COX-1, with an IC₅₀ of 1.86 μM and a selectivity index of 4.70^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

COX-2-IN-70 (compound 10f) (50 mg/kg; p.o.; single administration; administered 60 min before inflammation induction, with observation up to the 5th h after inflammation induction) exhibits significant anti-inflammatory and edema-reducing activity in the Carrageenan (HY-125474)-induced rat paw edema model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rat (average body weight 180 g, modeled by subplantar injection of 100 μL of 1% carrageenan in saline)^[1]
Dosage:

50 mg/kg
Administration:

p.o.; single dose; administered 60 minutes before the carrageenan injection, processed and evaluated at 1, 3, and 5 hours post-modeling.
Result:

Animal modeling method:
Dose:
Demonstrated a paw edema inhibition rate of 54.94%, exhibiting anti-edema efficacy significantly superior to the standard reference drugs indomethacin and celecoxib.
Significantly alleviated inflammation and edema in paw tissues, promoted tissue regeneration and recovery, and reduced neutrophil migration.
Maximally preserved the glandular mucosal and submucosal tissue architecture without causing significant gastrointestinal damage, such as ulceration and epithelial desquamation induced by indomethacin, indicating an excellent gastrointestinal safety profile.
Reduced the levels of TNF-α, IL-6, and PGE2 in paw tissues.

Chemical Information

Molecular Weight 634.60
Formel C₂₆H₁₈N₈O₈S₂
SMILES

O=C(CSC1=NN=C(O1)C2=CC=C(C=C2)C3=NN=C(O3)SCC(NC4=CC=C(C=C4)[N+]([O-])=O)=O)NC(C=C5)=CC=C5[N+]([O-])=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. El-Hady, O. M., et al. Upcycling PET waste into novel bis-1,3,4-oxadiazole scaffolds as promising anti-inflammatory agents: Synthesis, biological evaluation, and molecular docking. ACS Sustainable Chemistry & Engineering, 14(33), 15009-15025.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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