CRBN ligand-109
Based on 1 Customer Validation
CRBN ligand-109 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.
For research use only. We do not sell to patients.
- Purity: 99.35%
- CAS No.: 2758533-77-4
- Formula: C11H8BrF2NO2
- Molecular Weight:304.09
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Ubiquitination Compound Library
HY-L050
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E3 Ligase Ligand Library
HY-L128
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Molecular Glue-like Compound Library
HY-L918
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Anti-Cancer Compound Library
HY-L025
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2758533-77-4
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Appearance Solid
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Molecular Weight 304.09
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Formula C11H8BrF2NO2
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Color White to off-white
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SMILES
O=C(C(C1=C(F)C=C(Br)C=C1F)CC2)NC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (328.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2885 mL | 16.4425 mL | 32.8850 mL | 82.2125 mL |
| 5 mM | 0.6577 mL | 3.2885 mL | 6.5770 mL | 16.4425 mL | |
| 10 mM | 0.3289 mL | 1.6443 mL | 3.2885 mL | 8.2213 mL | |
| 15 mM | 0.2192 mL | 1.0962 mL | 2.1923 mL | 5.4808 mL | |
| 20 mM | 0.1644 mL | 0.8221 mL | 1.6443 mL | 4.1106 mL | |
| 25 mM | 0.1315 mL | 0.6577 mL | 1.3154 mL | 3.2885 mL | |
| 30 mM | 0.1096 mL | 0.5481 mL | 1.0962 mL | 2.7404 mL | |
| 40 mM | 0.0822 mL | 0.4111 mL | 0.8221 mL | 2.0553 mL | |
| 50 mM | 0.0658 mL | 0.3289 mL | 0.6577 mL | 1.6443 mL | |
| 60 mM | 0.0548 mL | 0.2740 mL | 0.5481 mL | 1.3702 mL | |
| 80 mM | 0.0411 mL | 0.2055 mL | 0.4111 mL | 1.0277 mL | |
| 100 mM | 0.0329 mL | 0.1644 mL | 0.3289 mL | 0.8221 mL |
CRBN ligand-109 Related Classifications
HY-W440247 Related Classifications
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