Dapagliflozin impurity 111

Cat. No.: HY-I1119 Purity: 98.49%: Data Sheet
COA

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Dapagliflozin impurity 111 is an impurity of Dapagliflozin (HY-10450).

For research use only. We do not sell to patients.

Dapagliflozin impurity 111 Chemical Structure

CAS No. : 333359-90-3

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
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Other Forms of Dapagliflozin impurity 111:

Dapagliflozin impurity 111 (Standard) Get quote

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Biological Activity
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Description

Dapagliflozin impurity 111 is an impurity of Dapagliflozin (HY-10450).

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	1 nM Compound: 4	Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs	[PMID: 20149653]
CHO	IC₅₀	240 nM Compound: 4	Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs	[PMID: 20149653]

Molecular Weight

394.85

Formula

C₂₀H₂₃ClO₆

CAS No.

333359-90-3

Appearance

Solid

SMILES

ClC1=CC=C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=C1CC3=CC=C(OC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (253.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5326 mL	12.6630 mL	25.3261 mL
5 mM	0.5065 mL	2.5326 mL	5.0652 mL
10 mM	0.2533 mL	1.2663 mL	2.5326 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.49%

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Data Sheet (245 KB) SDS (393 KB)

COA (252 KB) RP-HPLC (141 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5326 mL	12.6630 mL	25.3261 mL	63.3152 mL
	5 mM	0.5065 mL	2.5326 mL	5.0652 mL	12.6630 mL
	10 mM	0.2533 mL	1.2663 mL	2.5326 mL	6.3315 mL
	15 mM	0.1688 mL	0.8442 mL	1.6884 mL	4.2210 mL
	20 mM	0.1266 mL	0.6332 mL	1.2663 mL	3.1658 mL
	25 mM	0.1013 mL	0.5065 mL	1.0130 mL	2.5326 mL
	30 mM	0.0844 mL	0.4221 mL	0.8442 mL	2.1105 mL
	40 mM	0.0633 mL	0.3166 mL	0.6332 mL	1.5829 mL
	50 mM	0.0507 mL	0.2533 mL	0.5065 mL	1.2663 mL
	60 mM	0.0422 mL	0.2111 mL	0.4221 mL	1.0553 mL
	80 mM	0.0317 mL	0.1583 mL	0.3166 mL	0.7914 mL
	100 mM	0.0253 mL	0.1266 mL	0.2533 mL	0.6332 mL