Ifnar1 - interferon alpha and beta receptor subunit 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 288264

About Ifnar1

Primary_assembly 11: 30,725,790-30,749,979 forward strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 226 orthologues, 11 paralogues and is associated with 19 phenotypes. Biased expression in Lung (RPKM 331.9), Spleen (RPKM 237.2) and 9 other tissues.

Summary

Predicted to enable type I interferon binding activity and type I interferon receptor activity. Involved in cytokine-mediated signaling pathway. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Ifnar1 Products (2)

mRNA Protein Name
NM_001271316.1 NP_001258245.1 interferon alpha/beta receptor 1 isoform 2
NM_001105893.1 NP_001099363.2 interferon alpha/beta receptor 1 isoform 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Verweise Source
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27999109 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ifnar1 Protein Structure

FN3

FN3: cl21522 (17 - 113)

Interfer-bind

Interfer-bind: pfam09294 (125 - 222)

FN3

FN3: cl21522 (221 - 316)

FN3

FN3: cl21522 (328 - 424)

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  • 593 a.a.
Protein Preferred Names Protein Names

interferon alpha/beta receptor 1

  • interferon (alpha and beta) receptor 1

  • interferon (alpha, beta and omega) receptor 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-137978A Ezurpimtrostat hydrochloride Inhibitor 99.26% Phase 2
HY-137978 Ezurpimtrostat Inhibitor 99.37% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-17663 KMR-206 Activator 98.86% Unkown
HY-P1758A IFN-α Receptor Recognition Peptide 1 acetate Modulator 99.29% Unkown
HY-P1758 IFN-α Receptor Recognition Peptide 1 Modulator / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P991251 QX006N Inhibitor 99.9% Unkown
HY-P992182 ANB032 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ifnar1 NCBI NCBI:3454
Macaca fascicularis Ifnar1 NCBI NCBI:101926190
Mus musculus Ifnar1 NCBI NCBI:15975
Macaca mulatta Ifnar1 NCBI NCBI:699604