AGXT2 - alanine--glyoxylate aminotransferase 2 Gene

Also Known as AGT2; BAIBA; DAIBAT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64902

About AGXT2

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:34,998,102-35,047,949 (from NCBI)

This gene has 6 transcripts (splice variants), 218 orthologues, 4 paralogues and is associated with 1 phenotype. Biased expression in kidney (RPKM 69.3) and liver (RPKM 24.9).

Summary

The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

AGXT2 Products (2)

mRNA Protein Name
NM_001306173.2 NP_001293102.1 alanine--glyoxylate aminotransferase 2, mitochondrial isoform b precursor
NM_031900.4 NP_114106.1 alanine--glyoxylate aminotransferase 2, mitochondrial isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity IDA
IDA: Inferred from direct assay
24586340 GOA
enables alanine-glyoxylate transaminase activity IDA
IDA: Inferred from direct assay
20018850 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in L-alanine catabolic process, by transamination IDA
IDA: Inferred from direct assay
20018850 GOA
involved in glycine biosynthetic process, by transamination of glyoxylate IDA
IDA: Inferred from direct assay
20018850 GOA
involved in glyoxylate catabolic process IDA
IDA: Inferred from direct assay
20018850 GOA
involved in positive regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
20018850 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in mitochondrion IDA
IDA: Inferred from direct assay
20018850 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGXT2 Protein Structure

Aminotran_3

Aminotran_3: Aminotransferase class-III (94 - 443)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
Protein Preferred Names Protein Names

alanine--glyoxylate aminotransferase 2, mitochondrial

  • (R)-3-amino-2-methylpropionate--pyruvate transaminase

Related Diseases

Diseases Alias
Beta-Aminoisobutyric Aciduria

  • Beta-Aminoisobutyric Acid, Urinary Excretion Of

  • BAIBA

  • Baib Urinary Excretion

  • Hyper-Beta-Aminoisobutyric Aciduria
Hyperoxaluria, Primary, Type Ii

  • Primary Hyperoxaluria Type 2

  • D-Glycerate Dehydrogenase Deficiency

  • Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency

  • HP2

  • Oxalosis Ii

  • Glyceric Aciduria

  • L-Glyceric Aciduria

  • Primary Hyperoxaluria, Type Ii

  • Oxalosis 2

  • Hyperoxaluria Primary 2

  • Hyperoxaluria Primary Type Ii

  • Ph2

  • Primary Hyperoxaluria Type Ii
Iminoglycinuria

  • Iminoglycinuria, Digenic

  • IG
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-W023323 (S)-β-Aminoisobutyric acid hydrochloride 99.90% Unkown
HY-RS00474 AGXT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus AGXT2 VGNC VGNC:97343
Rattus norvegicus AGXT2 RGD RGD:621767
Macaca mulatta AGXT2 VGNC VGNC:81349
Canis familiaris AGXT2 VGNC VGNC:50868
Mus musculus AGXT2 MGD MGI:2146052
Others AGXT2 NCBI