AKR7A3 - aldo-keto reductase family 7 member A3 Gene

Also Known as AFAR2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22977

About AKR7A3

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,274,229-19,288,770 (from NCBI)

This gene has 1 transcript (splice variant), 490 orthologues and 16 paralogues. Biased expression in duodenum (RPKM 81.0), small intestine (RPKM 50.3) and 6 other tissues.

Summary

Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]

AKR7A3 Products (1)

mRNA Protein Name
NM_012067.3 NP_036199.2 aflatoxin B1 aldehyde reductase member 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR7A3 Protein Structure

Aldo_ket_red

Aldo_ket_red: Aldo/keto reductase family (13 - 318)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
Protein Preferred Names Protein Names

aflatoxin B1 aldehyde reductase member 3

  • AFB1 aldehyde reductase 2

AKR7A3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AKR7A3 O95154 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
AKR7A3 O95154 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
AKR7A3 O95154 AKR7A2 Homo sapiens O43488
Anti Tag CoIP
33961781
Intra
AKR7A3 O95154 AKR7A2 Homo sapiens O43488
Anti Tag CoIP
28514442
Intra
AKR7A3 O95154 AKR7A2 Homo sapiens O43488
Y2H Array
31515488
Intra
AKR7A3 O95154 AKR7A3 Homo sapiens O95154
Y2H Array
32296183
Intra
AKR7A3 O95154 COMMD9 Homo sapiens Q9P000
Anti Tag CoIP
33961781
Intra
AKR7A3 O95154 AKR7L Homo sapiens Q8NHP1
Anti Tag CoIP
33961781
Intra
AKR7A3 O95154 AKR7A3 Homo sapiens O95154
Y2H Pooling
16189514
Intra
AKR7A3 O95154 COMMD9 Homo sapiens Q9P000
Anti Tag CoIP
28514442
Intra
AKR7A3 O95154 AKR7A3 Homo sapiens O95154
Y2H Prey Pooling
32296183
Intra
AKR7A3 O95154 AKR7L Homo sapiens Q8NHP1
Anti Tag CoIP
28514442
Intra
AKR7A3 O95154 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
AKR7A3 O95154 AKR7A3 Homo sapiens O95154
Y2H Array
31515488
Intra
AKR7A3 O95154 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
AKR7A3 O95154 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
AKR7A3 O95154 AKR7A3 Homo sapiens O95154
Validated Y2H
32296183
Intra
AKR7A3 O95154 AKR7A3 Homo sapiens O95154
Y2H Array
25416956
Intra
AKR7A3 O95154 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Intra
AKR7A3 O95154 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cytochrome P450 Oxidoreductase Deficiency

  • Por Deficiency

  • Pord

  • Antley-Bixler Syndrome With Disordered Steroidogenesis

  • Antley-Bixler Syndrome

  • Antley-Bixler Syndrome-Like Phenotype With Disordered Steroidogenesis

  • Combined Partial Deficiency Of 17-Hydroxylase And 21-Hydroxylase

  • Congenital Adrenal Hyperplasia Due To Apparent Combined P450c17 And P450c21 Deficiency

  • Antley-Bixler Syndrome, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00541 AKR7A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus AKR7A3 MGD MGI:107796
Rattus norvegicus AKR7A3 RGD RGD:628635
Others AKR7A3 NCBI