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Cat. No.: HY-187835

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WO677

WO677 is a KCNT1 inhibitor that can be used in studies of nervous system disorders associated with KCNT1 function, such as epilepsy.

For research use only. We do not sell to patients.

CAS No.: 3088105-77-2
Formula: C₁₈H₁₄F₆N₆O₂
Molecular Weight:460.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WO677 Chemical Structure

CAS No.: 3088105-77-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

WO677 is a KCNT1 inhibitor that can be used in studies of nervous system disorders associated with KCNT1 function, such as epilepsy^[1].

In Vitro

WO677 (I‑1a) exhibits an IC₅₀ ≤ 250 nM in the FLIPR calcium flux inhibition assay^[1].
WO677 can be obtained via trifluoroacetic acid treatment, palladium-catalyzed C-N coupling, titanium-mediated imine formation, and diastereomeric intermediate conversion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3088105-77-2
Molecular Weight 460.33
Formula C₁₈H₁₄F₆N₆O₂
SMILES

CN1N=C(C(F)(F)F)C=C1C(N[C@H]2COCC3=NN(C4=CC(C(F)(F)F)=NC=C4)C=C32)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stock N S. Heterocyclic compounds useful as kcnt1 inhibitors. WO2025117677A1, WIPO, 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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