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United States

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Cat. No.: HY-155446

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di-DTPA-LTL

di-DTPA-LTL is a bivalent hapten based on tyrosine-containing polypeptide design. di-DTPA-LTL has good hydrophilia and biological distribution. di-DTPA-LTL is labeled with ¹¹¹In (indium) and ¹³¹I (iodine). di-DTPA-LTL achieves tumor radioimmunoimaging in primary colorectal cancer patients with CEA by injecting a fixed low dose (5 mg) of bispecific antibody (anti-CEA x, anti-DTPA) and di-DTPA antigen peptide (labeled ¹¹¹In) into the patients.

For research use only. We do not sell to patients.

Formula: C₅₂H₈₂N₁₂O₂₃
Molecular Weight:1243.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

di-DTPA-LTL Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

Molecular Weight 1243.27
Formula C₅₂H₈₂N₁₂O₂₃
SMILES

OC(CN(CCN(CC(O)=O)CCN(CC(NCCCC[C@@H](C(N[C@H](CC1=CC=C(O)C=C1)C(N[C@@H](CCCCNC(CN(CCN(CCN(CCC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)=O)C(N)=O)=O)=O)NC(C)=O)=O)CC(O)=O)CC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gruaz-Guyon A, et al. Recent advances in pretargeted radioimmunotherapy. Curr Med Chem. 2005;12(3):319-38. [Content Brief]

[2]. Gautherot E, et al. Therapy for colon carcinoma xenografts with bispecific antibody‐targeted, iodine‐131‐labeled bivalent hapten[J]. Cancer: Interdisciplinary International Journal of the American Cancer Society, 1997, 80(S12): 2618-2623. [Content Brief]

[3]. Aarts F, et al. Pretargeted radioimmunoscintigraphy in patients with primary colorectal cancer using a bispecific anticarcinoembryonic antigen CEA X anti‐di‐diethylenetriaminepentaacetic acid F (ab′) 2 antibody[J]. Cancer, 2010, 116(S4): 1111-1117. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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