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United States

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Referencia número: HY-155446

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di-DTPA-LTL

di-DTPA-LTL is a bivalent hapten based on tyrosine-containing polypeptide design. di-DTPA-LTL has good hydrophilia and biological distribution. di-DTPA-LTL is labeled with ¹¹¹In (indium) and ¹³¹I (iodine). di-DTPA-LTL achieves tumor radioimmunoimaging in primary colorectal cancer patients with CEA by injecting a fixed low dose (5 mg) of bispecific antibody (anti-CEA x, anti-DTPA) and di-DTPA antigen peptide (labeled ¹¹¹In) into the patients.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₅₂H₈₂N₁₂O₂₃
Peso molecular:1243.27

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

di-DTPA-LTL Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Chemical Information

Peso molecular 1243.27
Fòrmula C₅₂H₈₂N₁₂O₂₃
SMILES

OC(CN(CCN(CC(O)=O)CCN(CC(NCCCC[C@@H](C(N[C@H](CC1=CC=C(O)C=C1)C(N[C@@H](CCCCNC(CN(CCN(CCN(CCC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)=O)C(N)=O)=O)=O)NC(C)=O)=O)CC(O)=O)CC(O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Gruaz-Guyon A, et al. Recent advances in pretargeted radioimmunotherapy. Curr Med Chem. 2005;12(3):319-38. [Content Brief]

[2]. Gautherot E, et al. Therapy for colon carcinoma xenografts with bispecific antibody‐targeted, iodine‐131‐labeled bivalent hapten[J]. Cancer: Interdisciplinary International Journal of the American Cancer Society, 1997, 80(S12): 2618-2623. [Content Brief]

[3]. Aarts F, et al. Pretargeted radioimmunoscintigraphy in patients with primary colorectal cancer using a bispecific anticarcinoembryonic antigen CEA X anti‐di‐diethylenetriaminepentaacetic acid F (ab′) 2 antibody[J]. Cancer, 2010, 116(S4): 1111-1117. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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