Dipropylene glycol 

Dipropylene glycol is a mixture of three structural isomers (2-(2-hydroxypropoxy)-1-propanol, 1,1'-oxybis (2-propanol), and 2,2'-oxybis (1-propanol)), and is also a toxic substance used in plasticizers, polyester resins, cosmetics, fragrances, polyurethane polyols, and alkyd resins. Dipropylene glycol induces liver and kidney damage as well as reproductive toxicity in rodents^[1].

Dipropylene glycol (2500-80,000 ppm; p.o.; ad libitum daily; 2 weeks, 3 months, or 2 years) administered via drinking water causes dose-dependent nonneoplastic toxic effects in F344/N rats, including reduced body weight gain, liver and kidney organ weight changes, histopathological lesions in the liver, kidney, nose, and reproductive tract, and significantly reduced survival (0% survival) in male rats at the 40,000 ppm 2-year dose due to exacerbated chronic nephropathy^[1].
Dipropylene glycol (5000-80,000 ppm; p.o.; ad libitum daily; 2 weeks, 3 months, or 2 years) administered via drinking water causes limited dose-dependent nonneoplastic toxic effects in B6C3F1 mice, including reduced body weight gain, liver organ weight changes, and centrilobular liver hypertrophy at high doses, with no treatment-related lesions observed in the 2-year study, indicating mice are less susceptible to dipropylene glycol toxicity than rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

134.18

C₆H₁₄O₃

25265-71-8

Liquid (Density: 1.023 g/cm³)

OC(COC(C)CO)C.OC(C)COCC(C)O.OCC(C)OC(C)CO

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Hooth MJ, et al. Toxicology and carcinogenesis studies of dipropylene glycol in rats and mice. Toxicology. 2004;204(2-3):123-140.