β2AR agonist 7

β2AR agonist 7 (Compound 160) (2 h; 24 h) binds to human M3 receptors expressed on CHO cell membranes with high and sustained affinity, with a K_i value of 1.86 nM at 2 h and 1.75 nM at 24 h^[1].
β2AR agonist 7 (0.25 h; 1 h) acts as a functional antagonist of human M3 receptors in CHO cells, with a K_B value of 38.0 nM at 0.25 h and 100 nM at 1 h^[1].
β2AR agonist 7 is a highly potent agonist of the human β2-adrenergic receptor, which induces intracellular cAMP accumulation with an EC₅₀ of 0.054 nM^[1].
The β2AR agonist 7 (0.5-10000 nM; tested via FLIPR calcium flux assay using CHO cells expressing hM₃; single pre-incubation; 0.25 or 1 h) antagonizes acetylcholine (Acetylcholine chloride, HY-B0282)-induced hM₃ signaling, with K_B values of 38 nM and 100 nM, respectively^[1].
β2AR agonist 7 (187 nM; isolated organ bath treatment; single treatment; monitored for 60 min with repeated carbachol stimulation) exhibits rapid onset and sustained vasodilatory effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .