Erbb4 - erb-b2 receptor tyrosine kinase 4 Gene

Also Known as Her4; c-erbB-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13869

About Erbb4

Chromosome 1: 68,071,345-69,147,218 reverse strand.GRCm39:CM000994.3

This gene has 5 transcripts (splice variants), 227 orthologues, 53 paralogues and is associated with 18 phenotypes. Biased expression in CNS E18 (RPKM 2.3), frontal lobe adult (RPKM 2.1) and 8 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in several processes, including mammary gland development; nervous system development; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including cellular response to epidermal growth factor stimulus; peptidyl-tyrosine autophosphorylation; and regulation of apoptotic process. Located in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; heart; and mammary gland primordium. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Erbb4 Products (1)

mRNA Protein Name
NM_010154.2 NP_034284.1 receptor tyrosine-protein kinase erbB-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GABA receptor binding IDA
IDA: Inferred from direct assay
24218551 MGI
enables epidermal growth factor receptor activity IGI
IGI: Inferred from genetic interaction
12621152 MGI
enables neuregulin receptor activity IDA
IDA: Inferred from direct assay
8702723 MGI
enables neuregulin receptor activity IMP
IMP: Inferred from mutant phenotype
19632177 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16061658 MGI
enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
9168114 MGI
Biological Process GO Annotation Evidence References Source
involved in ERBB2-ERBB4 signaling pathway IDA
IDA: Inferred from direct assay
8702723 MGI
involved in ERBB2-ERBB4 signaling pathway IGI
IGI: Inferred from genetic interaction
12621152 MGI
involved in ERBB4 signaling pathway IMP
IMP: Inferred from mutant phenotype
16446434 MGI
involved in ERBB4-ERBB4 signaling pathway IDA
IDA: Inferred from direct assay
8702723 MGI
involved in cardiac muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
19632177 MGI
acts upstream of or within cell fate commitment IDA
IDA: Inferred from direct assay
12399441 MGI
involved in cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
24218551 MGI
involved in cell surface receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
10508857 MGI
acts upstream of or within cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
8702723 MGI
involved in central nervous system morphogenesis IMP
IMP: Inferred from mutant phenotype
10655590 MGI
involved in embryonic pattern specification IMP
IMP: Inferred from mutant phenotype
10655590 MGI
acts upstream of or within establishment of planar polarity involved in nephron morphogenesis IMP
IMP: Inferred from mutant phenotype
22076439 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
7477376 MGI
involved in lactation IMP
IMP: Inferred from mutant phenotype
10508857 MGI
involved in mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
10508857 MGI
involved in mammary gland epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
16837552 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
7477376 MGI
involved in neural crest cell migration IMP
IMP: Inferred from mutant phenotype
10655590 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
22184199 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
22184199 MGI
involved in olfactory bulb interneuron differentiation IMP
IMP: Inferred from mutant phenotype
15543145 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16837552 MGI
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
19632177 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
18458158 MGI
acts upstream of or within positive regulation of protein localization to cell surface IGI
IGI: Inferred from genetic interaction
18458158 MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
16837552 MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
16837552 MGI
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
15543145 MGI
involved in synapse assembly IDA
IDA: Inferred from direct assay
20393464 MGI
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
20393464 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
20393464 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
20393464 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20393464 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
22184199 MGI
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
22184199 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
8702723 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
20393464 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
20393464 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Erbb4 Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (54 - 166)

Furin-like

Furin-like: pfam00757 (185 - 331)

Recep_L_domain

Recep_L_domain: pfam01030 (357 - 477)

GF_recep_IV

GF_recep_IV: pfam14843 (501 - 633)

TM_ErbB4

TM_ErbB4: cd12092 (641 - 684)

PTKc_HER4

PTKc_HER4: cd05110 (709 - 1011)

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  • 1200
  • 1292 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-4

  • avian erythroblastosis oncogene B 4

  • proto-oncogene-like protein c-ErbB-4

  • v-erb-a erythroblastic leukemia viral oncogene homolog 4

Erbb4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Erbb4 Q61527 WWOX Homo sapiens Q9NZC7
Confocal
16061658
Cross
Erbb4 Q61527 WWOX Homo sapiens Q9NZC7
Anti Tag CoIP
16061658
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13272 Dacomitinib 99.74% Yes

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B0793 AZ-5104 Inhibitor 99.91% Unkown
HY-N0353 Curdione Inhibitor 99.80% Unkown
HY-168438 ERBB agonist-1 99.16% Unkown
HY-18609 PD158780 Inhibitor 99.47% Unkown
HY-15375 Allitinib Inhibitor 98.88% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-13427 Allitinib tosylate Inhibitor 99.54% Unkown
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 96.78% Unkown
HY-112420 EGFR/ErbB-2-IN-2 Inhibitor 99.45% Unkown
HY-103441 JNJ28871063 hydrochloride Inhibitor 98.36% Unkown
HY-RS04472 ERBB4 Human Pre-designed siRNA Set A / Unkown
HY-13272S2 Dacomitinib-d10 dihydrochloride ≥95.0% Unkown
HY-E70715 ERBB2 775YVMA776 Recombinant Human Active Protein Kinase / Unkown
HY-B0793S1 AZ-5104-d2 Inhibitor / Unkown
HY-13272S3 Dacomitinib-d10 / Unkown
HY-175809 SRT6 Inhibitor / Unkown
HY-RS04473 Erbb4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04474 Erbb4 Rat Pre-designed siRNA Set A / Unkown
HY-174565 Human NRG3 mRNA / Unkown
HY-174671 Human HBEGF mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erbb4 NCBI NCBI:2066