ERBB4 - erb-b2 receptor tyrosine kinase 4 Gene

Also Known as HER4; ALS19; p180erbB4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2066

About ERBB4

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:211,375,717-212,538,802 (from NCBI)

This gene has 9 transcripts (splice variants), 227 orthologues, 53 paralogues and is associated with 146 phenotypes. Biased expression in kidney (RPKM 3.0), brain (RPKM 2.7) and 8 other tissues.

Summary

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by Neuregulins and Other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with Cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

ERBB4 Products (11)

mRNA	Protein	Name
NM_005235.3	NP_005226.1	receptor tyrosine-protein kinase erbB-4 isoform JM-a/CVT-1 precursor
XM_017003578.3	XP_016859067.1	receptor tyrosine-protein kinase erbB-4 isoform X2
XM_017003582.2	XP_016859071.1	receptor tyrosine-protein kinase erbB-4 isoform X9
XM_006712364.4	XP_006712427.1	receptor tyrosine-protein kinase erbB-4 isoform X5
XM_017003581.3	XP_016859070.1	receptor tyrosine-protein kinase erbB-4 isoform X6
NM_001042599.1	NP_001036064.1	receptor tyrosine-protein kinase erbB-4 isoform JM-a/CVT-2 precursor
XM_017003577.3	XP_016859066.1	receptor tyrosine-protein kinase erbB-4 isoform X1
XM_017003580.3	XP_016859069.1	receptor tyrosine-protein kinase erbB-4 isoform X4
XM_017003579.3	XP_016859068.1	receptor tyrosine-protein kinase erbB-4 isoform X3
XM_005246376.4	XP_005246433.1	receptor tyrosine-protein kinase erbB-4 isoform X7
XM_005246377.4	XP_005246434.1	receptor tyrosine-protein kinase erbB-4 isoform X8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables epidermal growth factor receptor binding	IPI IPI: Inferred from physical interaction	8617750	GOA
enables neuregulin receptor activity	IDA IDA: Inferred from direct assay	9275162	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9135143	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	18334220	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	18334220	GOA
enables transcription cis-regulatory region binding	IMP IMP: Inferred from mutant phenotype	15534001	GOA
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	18334220	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	9275162	GOA
involved in ERBB4-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	9275162	GOA
involved in cell migration	IDA IDA: Inferred from direct assay	9135143	GOA
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	10353604	GOA
involved in lactation	IMP IMP: Inferred from mutant phenotype	15534001	GOA
involved in mitochondrial fragmentation involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	16778220	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10722704	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17120616	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	18334220	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15534001	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	10348342	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8617750	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	15534001	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	16837552	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18334220	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	10572067	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12646923	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	16778220	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15534001	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	9275162	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERBB4 Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

Pkinase_Tyr

0
300
600
900
1200
1308 a.a.

Protein Preferred Names	Protein Names
receptor tyrosine-protein kinase erbB-4	avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4 human epidermal growth factor receptor 4 proto-oncogene-like protein c-ErbB-4 tyrosine kinase-type cell surface receptor HER4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

ERBB4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ERBB4	Q15303	ABL2	Homo sapiens	P42684	Protein Array	16273093
Intra	ERBB4	Q15303	NRG1	Homo sapiens	Q02297-6	SPR	28988771
Intra	ERBB4	Q15303	TROAP	Homo sapiens	Q12815	Anti Bait CoIP	17360433
Intra	ERBB4	Q15303	TROAP	Homo sapiens	Q12815	Pull Down	17360433
Intra	ERBB4	Q15303	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	ERBB4	Q15303	BYSL	Homo sapiens	Q13895	Pull Down	17360433
Intra	ERBB4	Q15303	BYSL	Homo sapiens	Q13895	Anti Bait CoIP	17360433
Intra	ERBB4	Q15303	ERBB3	Homo sapiens	P21860	Anti Bait CoIP	20227043
Intra	ERBB4	Q15303	ERBB3	Homo sapiens	P21860	Anti Bait CoIP	10572067
Intra	ERBB4	Q15303	SHC1	Homo sapiens	P29353	Pull Down	16729043
Intra	ERBB4	Q15303	SHC1	Homo sapiens	P29353	Protein Array	16273093
Intra	ERBB4	Q15303	DLG4	Homo sapiens	P78352	Anti Bait CoIP	10725395

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERBB4 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P70841	HER4 Protein, Human (HEK293, His)	Q15303-1 (Q26-R649)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73035	HER4 Protein, Human (HEK293, His-Fc)	Q15303-1 (Q26-P651)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78454	HER4 Protein, Human (HEK293, His-Avi)	Q15303-1 (Q26-P651)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700733	HER4 Protein, Human (Biotinylated, HEK293, His-Avi)	Q15303-1 (Q26-P651)	≥ 95%, as determined by reducing SDS-PAGE.

ERBB4 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80660	C-erbB-4/HER4 Antibody (YA456)	WB	Human, Rat
HY-P80660A	C-erbB-4/HER4 Antibody (YA456)(PBS only)	WB	Human, Rat

Related Diseases

Diseases	Alias
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Amyotrophic Lateral Sclerosis 19	Amyotrophic Lateral Sclerosis Type 19 ALS19 Sclerosis, Lateral, Amyotrophic, Type 19
Nk-Cell Enteropathy
Bronchiectasis 2
Childhood Medulloblastoma	Medulloblastoma, Childhood Pediatric Medulloblastoma Medulloblastoma Childhood
Peripartum Cardiomyopathy	Postpartum Cardiomyopathy Peripartum Cardiomyopathy, Susceptibility To Ppcm Ppcm, Susceptibility To Antepartum Peripartum Cardiomyopathy Postpartum Peripartum Cardiomyopathy Meadows' Syndrome Cardiomyopathy, Peripartum
Acneiform Dermatitis	Dermatitis Acneiform
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Tardive Dyskinesia	Drug-Induced Tardive Dyskinesia Lingual-Facial-Buccal Dyskinesia Neuroleptic-Induced Tardive Dyskinesia
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Squamous Blepharitis
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Mixed Cell Adenoma
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Paget Disease, Extramammary	Extramammary Paget Disease Cutaneous Paget'S Disease Paget Disease Extramammary Cutaneous Paget Disease Extramammary Paget'S Disease Paget'S Disease Of Skin Empd Extramammary Pagets Disease
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Gastroesophageal Adenocarcinoma	Gastric And Esophageal Adenocarcinoma Gastro-Esophageal Adenocarcinoma
Autosomal Dominant Non-Syndromic Intellectual Disability
Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant	Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans KFSD
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Vallecula Cancer	Malignant Tumor Of Vallecula
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-13272	Dacomitinib		99.74%	Yes

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-B0793	AZ-5104	Inhibitor	99.91%	Unkown
HY-N0353	Curdione	Inhibitor	99.80%	Unkown
HY-168438	ERBB agonist-1		99.16%	Unkown
HY-18609	PD158780	Inhibitor	99.47%	Unkown
HY-15375	Allitinib	Inhibitor	98.88%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-13427	Allitinib tosylate	Inhibitor	99.54%	Unkown
HY-103440	EGFR/ErbB-2/ErbB-4 inhibitor-3	Inhibitor	96.78%	Unkown
HY-112420	EGFR/ErbB-2-IN-2	Inhibitor	99.45%	Unkown
HY-103441	JNJ28871063 hydrochloride	Inhibitor	98.36%	Unkown
HY-RS04472	ERBB4 Human Pre-designed siRNA Set A		/	Unkown
HY-13272S2	Dacomitinib-d10 dihydrochloride		≥95.0%	Unkown
HY-E70715	ERBB2 775YVMA776 Recombinant Human Active Protein Kinase		/	Unkown
HY-B0793S1	AZ-5104-d2	Inhibitor	/	Unkown
HY-13272S3	Dacomitinib-d10		/	Unkown
HY-175809	SRT6	Inhibitor	/	Unkown
HY-RS04473	Erbb4 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04474	Erbb4 Rat Pre-designed siRNA Set A		/	Unkown
HY-174565	Human NRG3 mRNA		/	Unkown
HY-174671	Human HBEGF mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ERBB4	VGNC	VGNC:80198
Mus musculus	ERBB4	MGD	MGI:104771
Macaca mulatta	ERBB4	VGNC	VGNC:72253
Rattus norvegicus	ERBB4	RGD	RGD:620486
Canis familiaris	ERBB4	VGNC	VGNC:40437
Bos taurus	ERBB4	VGNC	VGNC:97270
Others	ERBB4	NCBI