CXCL2 - C-X-C motif chemokine ligand 2 Gene

Also Known as GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2920

About CXCL2

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:74,097,040-74,099,195 (from NCBI)

This gene has 3 transcripts (splice variants), 21 orthologues and 12 paralogues. Broad expression in liver (RPKM 52.2), gall bladder (RPKM 27.8) and 15 other tissues.

Summary

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]

CXCL2 Products (1)

mRNA	Protein	Name
NM_002089.4	NP_002080.1	C-X-C motif chemokine 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18275857	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in response to molecule of bacterial origin	IDA IDA: Inferred from direct assay	19912257	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL2 Protein Structure

IL8

0
100
107 a.a.

Protein Preferred Names	Protein Names
C-X-C motif chemokine 2	GRO2 oncogene

CXCL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CXCL2	P19875	PF4	Homo sapiens	P02776	SPR	28381538
Intra	CXCL2	P19875	PF4	Homo sapiens	P02776	Filter Binding	28381538
Intra	CXCL2	P19875	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CXCL2	P19875	CCL5	Homo sapiens	P13501	Filter Binding	28381538
Intra	CXCL2	P19875	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
Intra	CXCL2	P19875	CXCL12	Homo sapiens	P48061	SPR	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7190	GRO-beta/CXCL2 Protein, Human	P19875 (A35-N107)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700045AF	Animal-Free GRO-beta/CXCL2 Protein, Human (His)	P19875 (A35-N107)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Peritonitis	Retractile Mesenteritis Sclerosing Mesenteritis Acute Generalized Peritonitis Primary Bacterial Peritonitis Idiopathic Sclerosing Mesenteritis Mesenteric Panniculitis Peritoneal Retractile Mesenteritis Liposclerotic Mesenteritis Mesenteric Fibromatosis Mesenteric Lipodystrophy Mesenteric Lipogranuloma Fibromatosis, Abdominal Peritoneum Inflammation Peritonitis Of Undetermined Cause Peritonitis Of Unspecified Cause Pelviperitonitis Pelvic Peritonitis, Nos Generalised Peritonitis Nos Abdominal Peritonitis Acute Idiopathic Peritonitis Acute Lesser Sac Peritonitis Acute Peritoneal Inflammation Diffuse Peritonitis Peritoneal Inflammation Acute Primary Peritonitis Pneumococcal Peritonitis
Acanthamoeba Keratitis
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Meningoencephalitis	Acquired Toxoplasmal Meningoencephalitis Meningoencephalitis Due To Acquired Toxoplasmosis Meningoencephalitis Due To Toxoplasmosis Toxoplasma Meningoencephalitis
Keratitis, Hereditary	Keratitis Autosomal Dominant Keratitis Hereditary Keratitis Dominantly Inherited Keratitis Keratitis Hereditary KERH
Pyelonephritis
Colitis
Meningitis	Streptococcal Meningitis Acute Streptococcal Meningitis Staphylococcal Meningitis Adenoviral Meningitis Influenza Meningitis Influenzal Meningitis Meningitis Due To H. Influenzae Cryptococcal Meningitis Fungal Meningitis Due To Cryptococcus Neoformans Cryptococcosis Meningitis Cryptococcus Meningitis Cryptococcal Meningoencephalitis Meningitis Due To Cryptococcus Mumps Virus Meningitis Mumps Meningitis
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B1322A	Amodiaquine	99.92%	Unkown
HY-B1322	Amodiaquine dihydrochloride dihydrate	99.97%	Unkown
HY-B1322B	Amodiaquine dihydrochloride	99.97%	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168971	Paeoniflorin-6′-O-benzene sulfonate		/	Unkown
HY-B1322AS1	Amodiaquine-d10 hydrochloride		/	Unkown
HY-RS03391	CXCL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16653	Cxcl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23088	Cxcl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CXCL2	RGD	RGD:70069
Others	CXCL2	NCBI