2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. DM4-SMCC

DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker.

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DM4-SMCC

DM4-SMCC 構造式

CAS 番号 : 1228105-52-9

容量 価格（税別） 在庫状況 数量
1 mg $250 在庫あり
5 mg $550 在庫あり
10 mg $880 在庫あり
25 mg $1750 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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DM4-SMCC 関連抗体

Top Publications Citing Use of Products

Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

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  • 純度とドキュメンテーション

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製品説明

DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker[1].

IC50 & Target[1]

Maytansinoids

 

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DM4-SMCC 関連抗体
分子量

1114.69

分子式

C54H72ClN5O16S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(C)(C)SC(C5)C(N(CC6CCC(C(ON7C(CCC7=O)=O)=O)CC6)C5=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (112.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8971 mL 4.4856 mL 8.9711 mL
5 mM 0.1794 mL 0.8971 mL 1.7942 mL
10 mM 0.0897 mL 0.4486 mL 0.8971 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 96.86%

COA (257 KB) HNMR (376 KB) LCMS (94 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8971 mL 4.4856 mL 8.9711 mL 22.4278 mL
5 mM 0.1794 mL 0.8971 mL 1.7942 mL 4.4856 mL
10 mM 0.0897 mL 0.4486 mL 0.8971 mL 2.2428 mL
15 mM 0.0598 mL 0.2990 mL 0.5981 mL 1.4952 mL
20 mM 0.0449 mL 0.2243 mL 0.4486 mL 1.1214 mL
25 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8971 mL
30 mM 0.0299 mL 0.1495 mL 0.2990 mL 0.7476 mL
40 mM 0.0224 mL 0.1121 mL 0.2243 mL 0.5607 mL
50 mM 0.0179 mL 0.0897 mL 0.1794 mL 0.4486 mL
60 mM 0.0150 mL 0.0748 mL 0.1495 mL 0.3738 mL
80 mM 0.0112 mL 0.0561 mL 0.1121 mL 0.2803 mL
100 mM 0.0090 mL 0.0449 mL 0.0897 mL 0.2243 mL
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DM4-SMCC Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DM4-SMCC1228105-52-9Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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製品名:
DM4-SMCC
製品番号:
HY-126494
数量:
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