SPP-DM1
Based on 1 Customer Validation
SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP.
For research use only. We do not sell to patients.
- Purity: 96.29%
- CAS No.: 452072-20-7
- Formula: C44H59ClN4O14S2
- Molecular Weight:967.54
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
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Maytansinoids |
Chemical Information
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CAS No. 452072-20-7
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Appearance Solid
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Molecular Weight 967.54
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Formula C44H59ClN4O14S2
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Color White to off-white
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SMILES
C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCSSC(C)CCC(ON5C(CCC5=O)=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (103.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0335 mL | 5.1677 mL | 10.3355 mL | 25.8387 mL |
| 5 mM | 0.2067 mL | 1.0335 mL | 2.0671 mL | 5.1677 mL | |
| 10 mM | 0.1034 mL | 0.5168 mL | 1.0335 mL | 2.5839 mL | |
| 15 mM | 0.0689 mL | 0.3445 mL | 0.6890 mL | 1.7226 mL | |
| 20 mM | 0.0517 mL | 0.2584 mL | 0.5168 mL | 1.2919 mL | |
| 25 mM | 0.0413 mL | 0.2067 mL | 0.4134 mL | 1.0335 mL | |
| 30 mM | 0.0345 mL | 0.1723 mL | 0.3445 mL | 0.8613 mL | |
| 40 mM | 0.0258 mL | 0.1292 mL | 0.2584 mL | 0.6460 mL | |
| 50 mM | 0.0207 mL | 0.1034 mL | 0.2067 mL | 0.5168 mL | |
| 60 mM | 0.0172 mL | 0.0861 mL | 0.1723 mL | 0.4306 mL | |
| 80 mM | 0.0129 mL | 0.0646 mL | 0.1292 mL | 0.3230 mL | |
| 100 mM | 0.0103 mL | 0.0517 mL | 0.1034 mL | 0.2584 mL |
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