DOPE-PEG2000-WLSEAGPVVTVRALRGTGSW

DOPE-PEG2000-WLSEAGPVVTVRALRGTGSW: surface decoration of liposomes and lipid nanoparticles for tissue-targeted drug delivery, enabling selective drug accumulation in specific tissues identified through phage display biopanning.
Structural composition:
(1) DOPE; a phospholipid with two unsaturated oleoyl chains that anchors into lipid bilayers and provides fusogenic activity for endosomal escape;
(2) PEG2000; a hydrophilic polymer that creates a steric barrier reducing opsonization and RES clearance, prolonging circulation time;
(3) WLSEAGPVVTVRALRGTGSW peptide; a 20-residue targeting peptide identified by phage display that specifically recognizes and binds to receptors or surface markers on target tissue cells, directing nanocarriers to specific tissues for enhanced drug accumulation and therapeutic efficacy while reducing systemic side effects.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .