DTLMISR acetate
DTLMISR acetate is a tryptic peptide widely present in the Fc regions of all four human IgG subclasses. DTLMISR acetate contains a methionine residue susceptible to both post-translational modification oxidation and artificial oxidation, and its oxidized form requires specific detection via LC-MRM before SILuMAb aliquoting and storage.
For research use only. We do not sell to patients.
- Formula: C34H62N10O12S·xC2H42
- Molecular Weight:834.98 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 834.98 (free base)
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Formula C34H62N10O12S·xC2H42
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Color White to off-white
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SMILES
O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CO)=O)[C@H](CC)C)=O)CCSC)=O)CC(C)C)=O)[C@@H](C)O.CC(O)=O.[x]
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Sequence
Asp-Thr-Leu-Met-Ile-Ser-Arg
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Sequence Shortening
DTLMISR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Lesur A, Varesio E, Hopfgartner G. Protein quantification by MALDI-selected reaction monitoring mass spectrometry using sulfonate derivatized peptides. Analytical chemistry. 2010 Jun 15;82(12):5227-37. [Content Brief]
[2]. Vialaret J, Broutin S, Pugnier C, et al.. What sample preparation should be chosen for targeted MS monoclonal antibody quantification in human serum?. Bioanalysis. 2018 May 01;10(10):723-735. [Content Brief]
[3]. Hong Q, Lebrilla CB, Miyamoto S, et al.. Absolute quantitation of immunoglobulin G and its glycoforms using multiple reaction monitoring. Analytical chemistry. 2013 Sep 17;85(18):8585-93. [Content Brief]
[4]. Kleinberg A, Yoon J, Mao Y, et al.. Eliminating liquid chromatography-induced methionine oxidation of monoclonal antibodies using high-concentration TCEP injections: The "anTCEPtic" column cleaning method. Journal of pharmaceutical sciences. 2026 Jun;115(6):104298. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DTLMISR acetate Related Classifications
HY-P11884A Related Classifications
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