(E/Z)-Platyphyllenone
(E/Z)-Platyphyllenone is a diarylheptanoid compound that can be found in Alnus viridis ssp. viridis. (E/Z)-Platyphyllenone inhibits the biosynthesis of violacein, but stimulates the production of AHL and AHQ quorum-sensing signal molecules as well as the synthesis of pyocyanin in Pseudomonas aeruginosa PAO1, and exhibits strong cytotoxicity against human lung fibroblasts. (E/Z)-Platyphyllenone can be used in studies on Pseudomonas aeruginosa.
For research use only. We do not sell to patients.
- CAS No.: 56973-65-0
- Formula: C19H20O3
- Molecular Weight:296.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(E/Z)-Platyphyllenone (Compound 7) (0.5 MIC; 24 h) does not inhibit early biofilm formation in Pseudomonas aeruginosa PAO1[1].
(E/Z)-Platyphyllenone (10-15 µg/mL) reduces twitching and swimming motility in Pseudomonas aeruginosa PAO1[1].
(E/Z)-Platyphyllenone (50 µg/mL; 24 h) stimulates pyocyanin production to 127% of control levels in Pseudomonas aeruginosa PAO1[1].
(E/Z)-Platyphyllenone (100 µg per disc) inhibits violacein production in Chromobacterium violaceum CV026[1].
(E/Z)-Platyphyllenone (50 µg/mL; 24 h) stimulates 2-alkyl-4-quinolones production to 150% of control levels (50% relative increase) in Pseudomonas aeruginosa PAO1[1].
(E/Z)-Platyphyllenone (1-100 µg/mL; 48 h) exhibits concentration-dependent antiproliferative activity against MRC5 human lung fibroblasts, with an IC50 of 70 µg/mL, inhibiting proliferation by ~95% at both 50 µg/mL and 100 µg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MRC5 human lung fibroblast cells
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Concentration:1, 10, 50 and 100 µg/mL
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Incubation Time:48 h
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Result:Inhibited cell proliferation in a concentration-dependent manner.
Inhibited proliferation by about 95% at 50 µg/mL.
Inhibited proliferation by about 95% at 100 µg/mL.
Exhibited an IC50 value of 70 µg/mL for antiproliferative activity.
Chemical Information
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CAS No. 56973-65-0
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Molecular Weight 296.37
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Formula C19H20O3
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SMILES
O=C(C=CCCC1=CC=C(O)C=C1)CCC2=CC=C(O)C=C2
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Structure Classification
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Initial Source
Alnusviridisssp
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E/Z)-Platyphyllenone Related Classifications
HY-N3043A Related Classifications
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