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Cat. No.: HY-172955

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E3 ligase Ligand 65

E3 ligase Ligand 65 is a ligand for E3 ligase, used for the synthesis of AZ'3137 (HY-162702) .

For research use only. We do not sell to patients.

CAS No.: 2417258-70-7
Formula: C₁₄H₁₄N₂O₅
Molecular Weight:290.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

E3 ligase Ligand 65 Chemical Structure

CAS No.: 2417258-70-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

E3 ligase Ligand 65 is a ligand for E3 ligase, used for the synthesis of AZ'3137 (HY-162702) ^[1].

IC₅₀ & Target

Cereblon

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 2417258-70-7
Molecular Weight 290.27
Formula C₁₄H₁₄N₂O₅
SMILES

COC1=CC(O)=CC2=C1C(N(C3CCC(NC3=O)=O)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bagal SK, et al. Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer. J Med Chem. 2024 Jul 25;67(14):11732-11750. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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E3 ligase Ligand 65

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

E3 ligase Ligand 65 Related Classifications

HY-172955 Related Classifications