AS-183
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC50=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC50 values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia.
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- No. CAS: 147317-12-2
- Fòrmula: C19H34O3
- Peso molecular:310.47
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
25.5 μM
Compound: 101; AS-183
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Reduction in cholesteryl ester synthesis in human Caco-2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
Reduction in cholesteryl ester synthesis in human Caco-2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
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[PMID: 36473091] |
| HepG2 | IC50 |
18.1 μM
Compound: 101; AS-183
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Reduction in cholesteryl ester synthesis in human HepG2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
Reduction in cholesteryl ester synthesis in human HepG2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
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[PMID: 36473091] |
| THP-1 | IC50 |
34.5 μM
Compound: 101; AS-183
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Reduction in cholesteryl ester synthesis in human THP-1 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
Reduction in cholesteryl ester synthesis in human THP-1 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
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[PMID: 36473091] |
Chemical Information
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No. CAS 147317-12-2
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Peso molecular 310.47
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Fòrmula C19H34O3
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SMILES
O=C1C(O)(OC(C(CC(CC(CC(CC)C)C)C)C)=C1C)C
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Structure Classification
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Initial Source
Scedosporium sp.
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS-183 Related Classifications
HY-129340 Related Classifications
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